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Dhiren R. Thakker

Affiliations: 
University of North Carolina, Chapel Hill, Chapel Hill, NC 
Area:
Pharmacy, Molecular Biology, Biochemistry
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Parents

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Children

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Kiho Lee grad student 2000 UNC Chapel Hill
Matthew D. Troutman grad student 2002 UNC Chapel Hill
Chee M. Ng grad student 2003 UNC Chapel Hill
Gururaj A. Rao grad student 2003 UNC Chapel Hill
Seongwon Hong grad student 2004 UNC Chapel Hill
David L. Bourdet grad student 2005 UNC Chapel Hill
Timothy K. Tippin grad student 2006 UNC Chapel Hill
Ryan R. Klein grad student 2007 UNC Chapel Hill
Beverly M. Knight grad student 2007 UNC Chapel Hill
Xin Ming grad student 2008 UNC Chapel Hill
Claudia N. Generaux grad student 2010 UNC Chapel Hill
Chester L. Costales grad student 2013 UNC Chapel Hill
Tianxiang Han grad student 2013 UNC Chapel Hill
Nathan D. Pfeifer grad student 2013 UNC Chapel Hill

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Publications

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Cai H, Everett R, Thakker DR. (2019) Efficacious Dose of Metformin for Breast Cancer Therapy is Determined by Cation Transporter Expression in Tumors. British Journal of Pharmacology
Muralidharan A, Guo H, Han J, et al. (2019) Abstract 3609: Metformin treatment outcomes in relation to obesity and cation transporter expression in mouse models of endometrial cancer Cancer Research
Muralidharan A, Bae-Jump VL, Thakker DR. (2018) Abstract 4916: OCT and MATE transporters mediate uptake and antiproliferative activity of the anticancer drug metformin in endometrial cancer cell lines Cancer Research. 78: 4916-4916
Lee CM, Thakker DR. (2018) Evidence for the role of OATP and PEPT1 transporters in the intestinal apical transport of amoxicillin Drug Metabolism and Pharmacokinetics. 33: S95
Zane NR, Chen Y, Wang MZ, et al. (2017) Cytochrome P450 and flavin-containing monooxygenase families: Age-dependent differences in expression and functional activity. Pediatric Research
Proctor WR, Ming X, Bourdet D, et al. (2016) Why Does the Intestine Lack Basolateral Efflux Transporters for Cationic Compounds? A Provocative Hypothesis. Journal of Pharmaceutical Sciences. 105: 484-96
Cai H, Zhang Y, Han TK, et al. (2015) Cation-selective transporters are critical to the ampk-mediated antiproliferative effects of metformin in human breast cancer cells. International Journal of Cancer. Journal International Du Cancer
Han TK, Proctor WR, Costales CL, et al. (2015) Four cation-selective transporters contribute to apical uptake and accumulation of metformin in Caco-2 cell monolayers. The Journal of Pharmacology and Experimental Therapeutics. 352: 519-28
Cai H, Wahajuddin M, Everett R, et al. (2014) Abstract 4639: Do cation-selective transporters help or hurt the antitumor efficacy of metformin in breast cancer Cancer Research. 74: 4639-4639
Alluri RV, Ward P, Kunta JR, et al. (2014) In vitro characterization of intestinal and hepatic transporters: MRP2 Methods in Pharmacology and Toxicology. 369-404
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