Bruce Demple
Affiliations: | Harvard University, Cambridge, MA, United States |
Area:
Molecular Biology, BiochemistryGoogle:
"Bruce Demple"Mean distance: (not calculated yet)
Parents
Sign in to add mentor| Stuart M. Linn | grad student | 1976-1981 | UC Berkeley |
| Tomas Robert Lindahl | post-doc |
Children
Sign in to add trainee| Arlen W. Johnson | grad student | Harvard (Cell Biology Tree) | |
| Jean Toby Greenberg | grad student | 1983-1989 | Harvard (Cell Biology Tree) |
| Donny Wong | grad student | 2003 | Harvard |
| Veronica Leautaud | grad student | 2004 | Harvard |
| Paul A. Auerbach | grad student | 2005 | Harvard |
| Tatsuo Nunoshiba | post-doc |
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Publications
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| Caston RA, Fortini P, Chen K, et al. (2023) Maintenance of Flap Endonucleases for Long-Patch Base Excision DNA Repair in Mouse Muscle and Neuronal Cells Differentiated In Vitro. International Journal of Molecular Sciences. 24 |
| Xue Z, Demple B. (2022) Knockout and Inhibition of Ape1: Roles of Ape1 in Base Excision DNA Repair and Modulation of Gene Expression. Antioxidants (Basel, Switzerland). 11 |
| Quiñones JL, Thapar U, Wilson SH, et al. (2020) Oxidative DNA-protein crosslinks formed in mammalian cells by abasic site lyases involved in DNA repair. Dna Repair. 87: 102773 |
| Thapar U, Demple B. (2019) Deployment of DNA polymerases beta and lambda in single-nucleotide and multinucleotide pathways of mammalian base excision DNA repair. Dna Repair. 76: 11-19 |
| Burra S, Marasco D, Malfatti MC, et al. (2019) Human AP-endonuclease (Ape1) activity on telomeric G4 structures is modulated by acetylatable lysine residues in the N-terminal sequence. Dna Repair. 73: 129-143 |
| Ströbel T, Madlener S, Tuna S, et al. (2017) Ape1 guides DNA repair pathway choice that is associated with drug tolerance in glioblastoma. Scientific Reports. 7: 9674 |
| Thapar U, Demple B. (2017) How are base excision DNA repair pathways deployed in vivo? F1000research. 6: 279 |
| Caston RA, Demple B. (2016) Risky repair: DNA-protein crosslinks formed by mitochondrial base excision DNA repair enzymes acting on free radical lesions. Free Radical Biology & Medicine |
| Quiñones JL, Demple B. (2016) When DNA repair goes wrong: BER-generated DNA-protein crosslinks to oxidative lesions. Dna Repair |
| Quiñones JL, Thapar U, Yu K, et al. (2015) Enzyme mechanism-based, oxidative DNA-protein cross-links formed with DNA polymerase β in vivo. Proceedings of the National Academy of Sciences of the United States of America |