Karen L. Milkiewicz, Ph.D.
Affiliations: | 2001 | State University of New York, Buffalo, Buffalo, NY, United States |
Area:
Organic ChemistryGoogle:
"Karen Milkiewicz"Mean distance: (not calculated yet)
Parents
Sign in to add mentor| David G. Hangauer | grad student | 2001 | SUNY Buffalo | |
| (Design, synthesis and biological testing of non-ATP competitive inhibitors of the pp60(c-src) protein tyrosine kinase.) | ||||
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Publications
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| Allwein SP, Mowrey DR, Petrillo DE, et al. (2017) Development of a Process Route to the FAK/ALK Dual Inhibitor TEV-37440 Organic Process Research & Development. 21: 740-747 |
| Dugan BJ, Gingrich DE, Mesaros EF, et al. (2012) A selective, orally bioavailable 1,2,4-triazolo[1,5-a]pyridine-based inhibitor of Janus kinase 2 for use in anticancer therapy: discovery of CEP-33779. Journal of Medicinal Chemistry. 55: 5243-54 |
| Zificsak CA, Gingrich DE, Breslin HJ, et al. (2012) Optimization of a novel kinase inhibitor scaffold for the dual inhibition of JAK2 and FAK kinases. Bioorganic & Medicinal Chemistry Letters. 22: 133-7 |
| Weinberg LR, Albom MS, Angeles TS, et al. (2011) 2,7-Pyrrolo[2,1-f][1,2,4]triazines as JAK2 inhibitors: modification of target structure to minimize reactive metabolite formation. Bioorganic & Medicinal Chemistry Letters. 21: 7325-30 |
| Milkiewicz KL, Aimone LD, Albom MS, et al. (2011) Improvement in oral bioavailability of 2,4-diaminopyrimidine c-Met inhibitors by incorporation of a 3-amidobenzazepin-2-one group. Bioorganic & Medicinal Chemistry. 19: 6274-84 |
| Weinberg LR, Albom MS, Angeles TS, et al. (2011) Fused bicyclic derivatives of 2,4-diaminopyrimidine as c-Met inhibitors. Bioorganic & Medicinal Chemistry Letters. 21: 164-7 |
| Milkiewicz KL, Ott GR. (2010) Inhibitors of anaplastic lymphoma kinase: a patent review. Expert Opinion On Therapeutic Patents. 20: 1653-81 |
| Milkiewicz KL, Weinberg LR, Albom MS, et al. (2010) Synthesis and structure-activity relationships of 1,2,3,4-tetrahydropyrido[2,3-b]pyrazines as potent and selective inhibitors of the anaplastic lymphoma kinase. Bioorganic & Medicinal Chemistry. 18: 4351-62 |
| Lee YK, Parks DJ, Lu T, et al. (2008) 7-fluoroindazoles as potent and selective inhibitors of factor Xa. Journal of Medicinal Chemistry. 51: 282-97 |
| Milkiewicz KL, Marsilje TH, Woodworth RP, et al. (2000) The design, synthesis and activity of non-ATP competitive inhibitors of pp60(c-src) tyrosine kinase. Part 2: hydroxyindole derivatives. Bioorganic & Medicinal Chemistry Letters. 10: 483-6 |