Michael P. Smolinski, Ph.D.
Affiliations: | 2006 | State University of New York, Buffalo, Buffalo, NY, United States |
Area:
Pharmaceutical ChemistryGoogle:
"Michael Smolinski"Mean distance: (not calculated yet)
Parents
Sign in to add mentor| David G. Hangauer | grad student | 2006 | SUNY Buffalo | |
| (Unraveling the thermodynamics of molecular recognition.) | ||||
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Publications
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| Pitzonka L, Cutler M, Lau JY, et al. (2019) Eribulin ORA: A novel oral formulation of eribulin based on combination with the P-gp inhibitor HM30181A. Journal of Clinical Oncology. 37 |
| Ciesielski MJ, Bu Y, Munich SA, et al. (2018) KX2-361: a novel orally bioavailable small molecule dual Src/tubulin inhibitor that provides long term survival in a murine model of glioblastoma. Journal of Neuro-Oncology |
| Smolinski MP, Bu Y, Clements J, et al. (2018) Discovery of Novel Dual Mechanism of Action Src Signaling and Tubulin Polymerization Inhibitors (KX2-391 and KX2-361). Journal of Medicinal Chemistry |
| Baum B, Muley L, Smolinski M, et al. (2010) Non-additivity of functional group contributions in protein-ligand binding: a comprehensive study by crystallography and isothermal titration calorimetry. Journal of Molecular Biology. 397: 1042-54 |
| Muley L, Baum B, Smolinski M, et al. (2010) Enhancement of hydrophobic interactions and hydrogen bond strength by cooperativity: synthesis, modeling, and molecular dynamics simulations of a congeneric series of thrombin inhibitors. Journal of Medicinal Chemistry. 53: 2126-35 |
| Bu Y, Smolinski M, Qu J, et al. (2010) Abstract 2487: Mechanism of action KX01 (KX2-391), a novel tubulin polymerization and Src signaling inhibitor proceeding to Phase II clinical trials Cancer Research. 70: 2487-2487 |
| Baum B, Muley L, Heine A, et al. (2009) Think twice: understanding the high potency of bis(phenyl)methane inhibitors of thrombin. Journal of Molecular Biology. 391: 552-64 |
| Gerlach C, Smolinski M, Steuber H, et al. (2007) Thermodynamic inhibition profile of a cyclopentyl and a cyclohexyl derivative towards thrombin: the same but for different reasons. Angewandte Chemie (International Ed. in English). 46: 8511-4 |
| Gerlach C, Smolinski M, Steuber H, et al. (2007) Thermodynamisches Inhibitionsprofil eines Cyclopentyl- und eines Cyclohexylderivats gegenüber Thrombin: gleich, jedoch aus unterschiedlichem Grund Angewandte Chemie. 119: 8664-8667 |