Daniel G. Isom, Ph.D.

Affiliations: 
2006 Johns Hopkins University, Baltimore, MD 
Area:
General Biophysics
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"Daniel Isom"
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Parents

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Bertrand Garcia-Moreno grad student 2006 Johns Hopkins
 (pKa values of internal ionizable groups in staphylococcal nuclease.)
Henrik G. Dohlman post-doc 2010-2016 UNC Chapel Hill (Physics Tree)
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Publications

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Rowe JB, Kapolka NJ, Taghon GJ, et al. (2020) The evolution and mechanism of GPCR proton sensing. The Journal of Biological Chemistry. 296: 100167
Rowe JB, Kapolka NJ, Taghon GJ, et al. (2020) The evolution and mechanism of GPCR proton sensing. The Journal of Biological Chemistry
Luna LA, Lesecq Z, White KA, et al. (2020) An acidic residue buried in the dimer interface of isocitrate dehydrogenase 1 (IDH1) helps regulate catalysis and pH sensitivity. The Biochemical Journal
Kapolka NJ, Taghon GJ, Rowe JB, et al. (2020) DCyFIR: a high-throughput CRISPR platform for multiplexed G protein-coupled receptor profiling and ligand discovery. Proceedings of the National Academy of Sciences of the United States of America
Rowe JB, Taghon GJ, Kapolka NJ, et al. (2020) CRISPR-addressable yeast strains with applications in human G protein-coupled receptor profiling and synthetic biology. The Journal of Biological Chemistry
Rowe J, Kapolka N, Taghon G, et al. (2020) Mechanistic Insights into pH‐sensing GPCRs The Faseb Journal. 34: 1-1
Isom DG, Page SC, Collins LB, et al. (2017) Coordinated Regulation of Intracellular pH by Two Glucose Sensing Pathways in Yeast. The Journal of Biological Chemistry
Shellhammer JP, Morin-Kensicki E, Matson JP, et al. (2017) Amino acid metabolites that regulate G protein signaling during osmotic stress. Plos Genetics. 13: e1006829
Isom DG, Sridharan V, Dohlman HG. (2016) Regulation of Ras Paralog Thermostability by Networks of Buried Ionizable Groups. Biochemistry. 55: 534-42
Isom DG, Dohlman HG. (2015) Buried ionizable networks are an ancient hallmark of G protein-coupled receptor activation. Proceedings of the National Academy of Sciences of the United States of America. 112: 5702-7
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