Chetan S. Karyekar, Ph.D.

Affiliations: 
2002 University of Maryland School of Medicine, Baltimore, MD, United States 
Area:
Pharmacology, Oncology, Pharmacy
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Natalie D. Eddington grad student 2002 University of Maryland Medical School
 (Effect of the tight junction modulator Zonula occludens toxin (Zot) and the P-glycoprotein inhibitor itraconazole on brain transport enhancement and their potential for renal drug interactions.)
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Publications

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Menon D, Karyekar CS, Fasano A, et al. (2005) Enhancement of brain distribution of anticancer agents using DeltaG, the 12 kDa active fragment of ZOT. International Journal of Pharmaceutics. 306: 122-31
Karyekar CS, Pradhan RS, Freeney T, et al. (2005) A phase I multiple-dose escalation study characterizing pharmacokinetics and safety of ABT-578 in healthy subjects. Journal of Clinical Pharmacology. 45: 910-8
Karyekar CS, Eddington ND, Briglia A, et al. (2004) Renal interaction between itraconazole and cimetidine. Journal of Clinical Pharmacology. 44: 919-27
Iqbal T, Karyekar CS, Kinjo M, et al. (2004) Validation of a simplified method for determination of cimetidine in human plasma and urine by liquid chromatography with ultraviolet detection. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 799: 337-41
Dowling TC, Briglia AE, Fink JC, et al. (2003) Characterization of hepatic cytochrome p4503A activity in patients with end-stage renal disease. Clinical Pharmacology and Therapeutics. 73: 427-34
Karyekar CS, Eddington ND, Garimella TS, et al. (2003) Evaluation of P-glycoprotein-mediated renal drug interactions in an MDR1-MDCK model. Pharmacotherapy. 23: 436-42
Karyekar CS, Fasano A, Raje S, et al. (2003) Zonula occludens toxin increases the permeability of molecular weight markers and chemotherapeutic agents across the bovine brain microvessel endothelial cells. Journal of Pharmaceutical Sciences. 92: 414-23
Karyekar CS, Eddington ND, Dowling TC. (2002) Effect of St. John's Wort extract on intestinal expression of cytochrome P4501A2: studies in LS180 cells. Journal of Postgraduate Medicine. 48: 97-100
Kamimori GH, Karyekar CS, Otterstetter R, et al. (2002) The rate of absorption and relative bioavailability of caffeine administered in chewing gum versus capsules to normal healthy volunteers. International Journal of Pharmaceutics. 234: 159-67
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