Zhijun Guo, Ph.D.

Affiliations: 
2004 University of Minnesota, Twin Cities, Minneapolis, MN 
Area:
Toxicology, Pharmacy, Biochemistry
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"Zhijun Guo"
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Patrick E. Hanna grad student 2004 UMN
 (Studies on hamster recombinant arylamine N-acetyltransferases: Part I. Covalent modification and inactivation of rNAT1 by bromoacetamido derivatives of aniline and 2-aminofluorene. Part II. Mass spectrometric investigation of the inactivation of rNAT1 by )
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Publications

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Guo Z, Lei J, Wu S, et al. (2020) Abstract 4372: Metformin inhibits nuclear localization of estrogen receptor alpha in breast cancer cells, in part, by inhibition of CYP-mediated epoxyeicosatrienoic acid (EET) biosynthesis Epidemiology. 80: 4372-4372
Guo Z, Wu S, Molina-Vega J, et al. (2019) Abstract LB-023: CYP monooxygenases regulate nuclear localization of ERá and mTORC1 component RagC in ER+HER2- breast cancer cells Cancer Research. 79
Guo Z, Johnson V, Barrera J, et al. (2018) Targeting cytochrome P450-dependent cancer cell mitochondria: cancer associated CYPs and where to find them. Cancer Metastasis Reviews
Guo Z, Sevrioukova IF, Denisov IG, et al. (2017) Heme Binding Biguanides Target Cytochrome P450-Dependent Cancer Cell Mitochondria. Cell Chemical Biology
Guo Z, Sevrioukova I, Hanse E, et al. (2016) Abstract 44: Hexyl-benzyl-biguanide (HBB) potently and selectively inhibits CYP3A4 epoxygenase activity and inhibits EET stabilization of mitochondrial respiration in ER+HER2- breast cancer cells, inducing glycolysis and pyruvate biosynthesis Cancer Research. 76: 44-44
Grossmann ME, Yang DQ, Guo Z, et al. (2015) Metformin Treatment for the Prevention and/or Treatment of Breast/Mammary Tumorigenesis. Current Pharmacology Reports. 1: 312-323
Guo Z, Chu H, Berger AC, et al. (2015) Effects of lumpectomy or mastectomy on plasma epoxyeicosatrienoic acid levels in patients with estrogen receptor positive, HER2-negative breast cancer. Journal of Clinical Oncology. 33
Guo Z, Chavez KJ, Alvarez J, et al. (2014) Abstract 2689: Breast cancer inhibition by a novel and potent biguanide, N1-hexyl-N5-benzyl-biguanide Cancer Research. 74: 2689-2689
Guo Z, Norris B, Henriksen J, et al. (2013) Abstract 82: CYP3A4 promotes mammary carcinoma angiogenesis in a cell iIntrinsic fashion. Cancer Research. 73: 82-82
Guo Z, Mitra R, Luo X, et al. (2012) Abstract 942: CYP3A4 epoxygenase mediates hypoxia-induced biosynthesis of epoxyeicosatrienoic acids (±)-11,12- and (±)-14,15-EET in breast cancer cells Cancer Research. 72: 942-942
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