Henry M. Miziorko

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Addo JK, Skaff DA, Miziorko HM. (2016) Active site binding modes of inhibitors of Staphylococcus aureus mevalonate diphosphate decarboxylase from docking and molecular dynamics simulations. Journal of Molecular Modeling. 22: 13
Kang HB, Fan J, Lin R, et al. (2015) Metabolic Rewiring by Oncogenic BRAF V600E Links Ketogenesis Pathway to BRAF-MEK1 Signaling. Molecular Cell
Skaff DA, McWhorter WJ, Geisbrecht BV, et al. (2015) Inhibition of bacterial mevalonate diphosphate decarboxylase by eriochrome compounds. Archives of Biochemistry and Biophysics. 566: 1-6
Vannice JC, Skaff DA, Keightley A, et al. (2014) Identification in Haloferax volcanii of phosphomevalonate decarboxylase and isopentenyl phosphate kinase as catalysts of the terminal enzyme reactions in an archaeal alternate mevalonate pathway. Journal of Bacteriology. 196: 1055-63
VanNice JC, Skaff DA, Wyckoff GJ, et al. (2013) Expression in Haloferax volcanii of 3-hydroxy-3-methylglutaryl coenzyme A synthase facilitates isolation and characterization of the active form of a key enzyme required for polyisoprenoid cell membrane biosynthesis in halophilic archaea. Journal of Bacteriology. 195: 3854-62
Boonsri P, Neumann TS, Olson AL, et al. (2013) Molecular docking and NMR binding studies to identify novel inhibitors of human phosphomevalonate kinase. Biochemical and Biophysical Research Communications. 430: 313-9
Moldover B, Solidar A, Montgomery C, et al. (2012) ChemVassa: A New Method for Identifying Small Molecule Hits in Drug Discovery. The Open Medicinal Chemistry Journal. 6: 29-34
Montgomery C, Pei Z, Watkins PA, et al. (2012) Identification and characterization of an extramitochondrial human 3-hydroxy-3-methylglutaryl-CoA lyase. The Journal of Biological Chemistry. 287: 33227-36
Barta ML, McWhorter WJ, Miziorko HM, et al. (2012) Structural basis for nucleotide binding and reaction catalysis in mevalonate diphosphate decarboxylase. Biochemistry. 51: 5611-21
Skaff DA, Ramyar KX, McWhorter WJ, et al. (2012) Biochemical and structural basis for inhibition of Enterococcus faecalis hydroxymethylglutaryl-CoA synthase, mvaS, by hymeglusin. Biochemistry. 51: 4713-22