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Marcos E. Milla

Affiliations: 
University of Pennsylvania, Philadelphia, PA, United States 
Area:
Biochemistry
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"Marcos Milla"
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Patricia E. Gonzales grad student 2005 Penn
Mohita J. Mohan grad student 2005 Penn
Soo-Hwa Kim grad student 2006 Penn

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Publications

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Gonzales PE, Galli JD, Milla ME. (2008) Identification of key sequence determinants for the inhibitory function of the prodomain of TACE. Biochemistry. 47: 9911-9
Sagi I, Milla ME. (2008) Application of structural dynamic approaches provide novel insights into the enzymatic mechanism of the tumor necrosis factor-alpha-converting enzyme. Analytical Biochemistry. 372: 1-10
Solomon A, Akabayov B, Frenkel A, et al. (2007) Key feature of the catalytic cycle of TNF-alpha converting enzyme involves communication between distal protein sites and the enzyme catalytic core. Proceedings of the National Academy of Sciences of the United States of America. 104: 4931-6
Milla ME, Gonzales PE. (2007) Key residues in the prodomain of TACE determining its inhibition of the catalytic domain The Faseb Journal. 21
Milla ME, Gonzales PE, Leonard JD. (2006) The TACE zymogen: re-examining the role of the cysteine switch. Cell Biochemistry and Biophysics. 44: 342-8
Leonard JD, Lin F, Milla ME. (2005) Chaperone-like properties of the prodomain of TNFalpha-converting enzyme (TACE) and the functional role of its cysteine switch. The Biochemical Journal. 387: 797-805
Solomon A, Rosenblum G, Gonzales PE, et al. (2004) Pronounced diversity in electronic and chemical properties between the catalytic zinc sites of tumor necrosis factor-α-converting enzyme and matrix metalloproteinases despite their high structural similarity Journal of Biological Chemistry. 279: 31646-31654
Gonzales PE, Solomon A, Miller AB, et al. (2004) Inhibition of the tumor necrosis factor-alpha-converting enzyme by its pro domain. The Journal of Biological Chemistry. 279: 31638-45
Hinkle CL, Mohan MJ, Lin P, et al. (2003) Multiple metalloproteinases process protransforming growth factor-alpha (proTGF-alpha). Biochemistry. 42: 2127-36
Mohan MJ, Seaton T, Mitchell J, et al. (2002) The tumor necrosis factor-alpha converting enzyme (TACE): a unique metalloproteinase with highly defined substrate selectivity. Biochemistry. 41: 9462-9
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