Jonathan M. Shaffer, Ph.D.

Affiliations: 
2008 University of Pittsburgh, Pittsburgh, PA, United States 
Area:
Molecular Biology, Cell Biology, Genetics
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"Jonathan Shaffer"
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Thomas E. Smithgall grad student 2008 University of Pittsburgh
 (Investigating the regulation of c-Fes non-receptor tyrosine kinase activation and gene expression.)
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Publications

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Shaffer JM, Hellwig S, Smithgall TE. (2009) Bimolecular fluorescence complementation demonstrates that the c-Fes protein-tyrosine kinase forms constitutive oligomers in living cells. Biochemistry. 48: 4780-8
Shaffer JM, Smithgall TE. (2009) Promoter methylation blocks FES protein-tyrosine kinase gene expression in colorectal cancer. Genes, Chromosomes & Cancer. 48: 272-84
Delfino FJ, Shaffer JM, Smithgall TE. (2006) The KRAB-associated co-repressor KAP-1 is a coiled-coil binding partner, substrate and activator of the c-Fes protein tyrosine kinase. The Biochemical Journal. 399: 141-50
Shaffer JM, Karandikar UC, Bidwai AP. (2006) An activity-based two-hybrid system for the selective identification of substrates of protein kinases. Analytical Biochemistry. 355: 154-6
Karandikar UC, Shaffer J, Bishop CP, et al. (2005) Drosophila CK2 phosphorylates Deadpan, a member of the HES family of basic-helix-loop-helix (bHLH) repressors. Molecular and Cellular Biochemistry. 274: 133-9
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