Damith G. Udugamasooriya, Ph.D.

Affiliations: 
2006 Wayne State University, Detroit, MI, United States 
Area:
Biochemistry, Biomedical Engineering, Pharmaceutical Chemistry
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"Damith Udugamasooriya"
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Mark Spaller grad student 2006 Wayne State
 (Design, synthesis and thermodynamic evaluation of peptide ligands for PDZ domain proteins.)
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Publications

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Kedika SR, Udugamasooriya DG. (2019) Converting a weaker ATP-binding site inhibitor into a potent hetero-bivalent ligand by tethering to a unique peptide sequence derived from the same kinase. Organic & Biomolecular Chemistry. 16: 6443-6449
Shukla SP, Udugamasooriya DG. (2017) A mini-library system to investigate non-essential residues of lipid-phosphatidylserine (PS) binding peptide-peptoid hybrid PPS1. Medchemcomm. 8: 2208-2215
Shukla SP, Manarang JC, Udugamasooriya DG. (2017) A unique mid-sequence linker used to multimerize the lipid-phosphatidylserine (PS) binding peptide-peptoid hybrid PPS1. European Journal of Medicinal Chemistry. 137: 1-10
Desai TJ, Udugamasooriya DG. (2017) A comprehensive lipid binding and activity validation of a cancer-specific peptide-peptoid hybrid PPS1. Biochemical and Biophysical Research Communications
Singh J, Shukla SP, Desai TJ, et al. (2016) Identification of the minimum pharmacophore of lipid-phosphatidylserine (PS) binding peptide-peptoid hybrid PPS1D1. Bioorganic & Medicinal Chemistry
Udugamasooriya DG, Kodadek T. (2012) On-Bead Two-Color (OBTC) Cell Screen for Direct Identification of Highly Selective Cell Surface Receptor Ligands. Current Protocols in Chemical Biology. 4: 35-48
Rubini C, Ruzza P, Spaller MR, et al. (2010) Recognition of lysine-rich peptide ligands by murine cortactin SH3 domain: CD, ITC, and NMR studies. Biopolymers. 94: 298-306
Muders MH, Vohra PK, Dutta SK, et al. (2009) Targeting GIPC/synectin in pancreatic cancer inhibits tumor growth. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 15: 4095-103
Udugamasooriya DG, Sharma SC, Spaller MR. (2008) A chemical library approach to organic-modified peptide ligands for PDZ domain proteins: a synthetic, thermodynamic and structural investigation. Chembiochem : a European Journal of Chemical Biology. 9: 1587-9
Udugamasooriya DG, Ritchie C, Brekken RA, et al. (2008) A peptoid antagonist of VEGF Receptor 2 recognizes a 'hotspot' in the extracellular domain distinct from the hormone-binding site Bioorganic and Medicinal Chemistry. 16: 6338-6343
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