Robert C. Tyler, Ph.D.

Affiliations: 
2003 Montana State University, Bozeman, MT 
Area:
Biochemistry, Molecular Biology
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"Robert Tyler"
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Valerie Copie grad student 2003 Montana State
 (NMR investigation of non-local effects in a temperature sensitive mutant of the 25 kD tryptophan repressor protein.)
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Publications

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Dishman AF, Tyler RC, Fox JC, et al. (2021) Evolution of fold switching in a metamorphic protein. Science (New York, N.Y.). 371: 86-90
Kleist AB, Peterson F, Tyler RC, et al. (2019) Solution NMR spectroscopy of GPCRs: Residue-specific labeling strategies with a focus on C-methyl methionine labeling of the atypical chemokine receptor ACKR3. Methods in Cell Biology. 149: 259-288
Nevins AM, Subramanian A, Tapia JL, et al. (2016) A Requirement for Metamorphic Interconversion in the Antimicrobial Activity of the Chemokine XCL1. Biochemistry
Fox JC, Tyler RC, Peterson FC, et al. (2016) Examination of Glycosaminoglycan Binding Sites on the XCL1 Dimer. Biochemistry
Fox JC, Tyler RC, Guzzo C, et al. (2015) Engineering Metamorphic Chemokine Lymphotactin/XCL1 into the GAG-Binding, HIV-Inhibitory Dimer Conformation. Acs Chemical Biology
Harvey SR, Porrini M, Tyler RC, et al. (2015) Electron capture dissociation and drift tube ion mobility-mass spectrometry coupled with site directed mutations provide insights into the conformational diversity of a metamorphic protein. Physical Chemistry Chemical Physics : Pccp. 17: 10538-50
Fox JC, Nakayama T, Tyler RC, et al. (2015) Structural and agonist properties of XCL2, the other member of the C-chemokine subfamily. Cytokine. 71: 302-11
Harvey SR, Porrini M, Konijnenberg A, et al. (2014) Dissecting the dynamic conformations of the metamorphic protein lymphotactin. The Journal of Physical Chemistry. B. 118: 12348-59
Tyler RC, Wieting JC, Peterson FC, et al. (2012) Electrostatic optimization of the conformational energy landscape in a metamorphic protein. Biochemistry. 51: 9067-75
Tyler RC, Murray NJ, Peterson FC, et al. (2011) Native-state interconversion of a metamorphic protein requires global unfolding. Biochemistry. 50: 7077-9
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