Chih-Chiun Chen, Ph.D.

Affiliations: 
2001 University of Illinois at Chicago, Health Sciences Center, Chicago, IL 60612, United States 
Area:
Cell Biology, Molecular Biology, Oncology
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Parents

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Lester F. Lau grad student 2001 Aurora University
 (Function of Cyr61 and CTGF in cell adhesive signaling, gene expression, wound healing and breast cancer.)
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Publications

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Chen CC, Chuang WT, Lin AH, et al. (2016) Andrographolide inhibits adipogenesis of 3T3-L1 cells by suppressing C/EBPβ expression and activation. Toxicology and Applied Pharmacology
Chen CC, Kim KH, Lau LF. (2015) The matricellular protein CCN1 suppresses hepatocarcinogenesis by inhibiting compensatory proliferation. Oncogene
Kim KH, Chen CC, Alpini G, et al. (2015) CCN1 induces hepatic ductular reaction through integrin αvβ₅-mediated activation of NF-κB. The Journal of Clinical Investigation. 125: 1886-900
Kim KH, Chen CC, Monzon RI, et al. (2013) Matricellular protein CCN1 promotes regression of liver fibrosis through induction of cellular senescence in hepatic myofibroblasts. Molecular and Cellular Biology. 33: 2078-90
Juric V, Chen CC, Lau LF. (2012) TNFα-induced apoptosis enabled by CCN1/CYR61: pathways of reactive oxygen species generation and cytochrome c release. Plos One. 7: e31303
Chen CC, Juric V, Lau LF. (2011) The extracellular matrix protein CCN1 dictates TNFα and FasL cytotoxicity in vivo. Advances in Experimental Medicine and Biology. 691: 595-603
Bai T, Chen CC, Lau LF. (2010) Matricellular protein CCN1 activates a proinflammatory genetic program in murine macrophages. Journal of Immunology (Baltimore, Md. : 1950). 184: 3223-32
Chen CC, Lau LF. (2010) Deadly liaisons: fatal attraction between CCN matricellular proteins and the tumor necrosis factor family of cytokines. Journal of Cell Communication and Signaling. 4: 63-9
Franzen CA, Chen CC, Todorović V, et al. (2009) Matrix protein CCN1 is critical for prostate carcinoma cell proliferation and TRAIL-induced apoptosis. Molecular Cancer Research : McR. 7: 1045-55
Juric V, Chen CC, Lau LF. (2009) Fas-mediated apoptosis is regulated by the extracellular matrix protein CCN1 (CYR61) in vitro and in vivo. Molecular and Cellular Biology. 29: 3266-79
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