Vimbai M. Chikwana, Ph.D.

Affiliations: 
2011 Chemistry Portland State University, Portland, OR, United States 
Area:
Biochemistry, Analytical Chemistry
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"Vimbai Chikwana"
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Dirk Iwata-Reuyl grad student 2011 Portland State University
 (Discovery of Novel Amidotransferase Activity Involved In Archaeosine Biosynthesis and Structural and Kinetic Investigation of QueF, an Enzyme Involved in Queuosine Biosynthesis.)
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Publications

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Tang B, Frasinyuk MS, Chikwana VM, et al. (2020) Discovery and development of small-molecule inhibitors of glycogen synthase. Journal of Medicinal Chemistry
Fortea E, Lemieux V, Potvin L, et al. (2017) Cry6Aa1, a Bacillus thuringiensis Nematocidal and Insecticidal Toxin, Forms Pores in Planar Lipid Bilayers at Extremely Low Concentrations and Without the Need of Proteolytic Processing. The Journal of Biological Chemistry
Dementiev A, Board J, Sitaram A, et al. (2016) The pesticidal Cry6Aa toxin from Bacillus thuringiensis is structurally similar to HlyE-family alpha pore-forming toxins. Bmc Biology. 14: 71
Contreras CJ, Segvich DM, Mahalingan K, et al. (2016) Incorporation of phosphate into glycogen by glycogen synthase. Archives of Biochemistry and Biophysics
Chikwana VM, Khanna M, Baskaran S, et al. (2013) Structural basis for 2'-phosphate incorporation into glycogen by glycogen synthase. Proceedings of the National Academy of Sciences of the United States of America. 110: 20976-81
Khanna M, Imasaki T, Chikwana VM, et al. (2013) Expression and purification of functional human glycogen synthase-1 (hGYS1) in insect cells. Protein Expression and Purification. 90: 78-83
Chikwana VM, Stec B, Lee BW, et al. (2012) Structural basis of biological nitrile reduction. The Journal of Biological Chemistry. 287: 30560-70
Baskaran S, Chikwana VM, Contreras CJ, et al. (2011) Multiple glycogen-binding sites in eukaryotic glycogen synthase are required for high catalytic efficiency toward glycogen. The Journal of Biological Chemistry. 286: 33999-4006
Rakovich T, Boland C, Bernstein I, et al. (2011) Queuosine deficiency in eukaryotes compromises tyrosine production through increased tetrahydrobiopterin oxidation. The Journal of Biological Chemistry. 286: 19354-63
Phillips G, Chikwana VM, Maxwell A, et al. (2010) Discovery and characterization of an amidinotransferase involved in the modification of archaeal tRNA. The Journal of Biological Chemistry. 285: 12706-13
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