Jason K. Yano, Ph.D.
Affiliations: | 2002 | University of California, Irvine, Irvine, CA |
Area:
Molecular BiologyGoogle:
"Jason Yano"Mean distance: (not calculated yet)
Parents
Sign in to add mentor| Eric S. Mankowski | grad student | Portland State University (PsychTree) | ||
| Thomas L. Poulos | grad student | 2002 | UC Irvine | |
| (A tale of two thermophiles: Determination and comparative analysis of two thermophile P450 structures.) | ||||
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Publications
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| Aikawa K, Asano M, Ono K, et al. (2017) Synthesis and biological evaluation of novel selective androgen receptor modulators (SARMs) Part III: Discovery of 4-(5-oxopyrrolidine-1-yl)benzonitrile derivative 2f as a clinical candidate. Bioorganic & Medicinal Chemistry |
| Asano M, Hitaka T, Imada T, et al. (2017) Synthesis and biological evaluation of novel selective androgen receptor modulators (SARMs). Part II: Optimization of 4-(pyrrolidin-1-yl)benzonitrile derivatives. Bioorganic & Medicinal Chemistry Letters |
| Lam B, Arikawa Y, Cramlett J, et al. (2016) Discovery of TAK-659 an orally available investigational inhibitor of Spleen Tyrosine Kinase (SYK). Bioorganic & Medicinal Chemistry Letters |
| Srivastava A, Yano J, Hirozane Y, et al. (2014) High-resolution structure of the human GPR40 receptor bound to allosteric agonist TAK-875. Nature. 513: 124-7 |
| Okaniwa M, Hirose M, Arita T, et al. (2013) Discovery of a selective kinase inhibitor (TAK-632) targeting pan-RAF inhibition: design, synthesis, and biological evaluation of C-7-substituted 1,3-benzothiazole derivatives. Journal of Medicinal Chemistry. 56: 6478-94 |
| Okaniwa M, Hirose M, Arita T, et al. (2013) Abstract C255: Discovery of TAK-632: A selective kinase inhibitor of pan-RAF with potent antitumor activity against BRAF and NRAS mutant melanomas. Molecular Cancer Therapeutics. 12 |
| Hirose M, Okaniwa M, Miyazaki T, et al. (2012) Design and synthesis of novel DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitors: 3. Evaluation of 5-amino-linked thiazolo[5,4-d]pyrimidine and thiazolo[5,4-b]pyridine derivatives. Bioorganic & Medicinal Chemistry. 20: 5600-15 |
| Okaniwa M, Hirose M, Imada T, et al. (2012) Design and synthesis of novel DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitors. 1. Exploration of [5,6]-fused bicyclic scaffolds. Journal of Medicinal Chemistry. 55: 3452-78 |
| Ishikawa T, Seto M, Banno H, et al. (2011) Design and synthesis of novel human epidermal growth factor receptor 2 (HER2)/epidermal growth factor receptor (EGFR) dual inhibitors bearing a pyrrolo[3,2-d]pyrimidine scaffold. Journal of Medicinal Chemistry. 54: 8030-50 |
| Banno Y, Miyamoto Y, Sasaki M, et al. (2011) Identification of 3-aminomethyl-1,2-dihydro-4-phenyl-1-isoquinolones: a new class of potent, selective, and orally active non-peptide dipeptidyl peptidase IV inhibitors that form a unique interaction with Lys554. Bioorganic & Medicinal Chemistry. 19: 4953-70 |