Julien A. Sebag, Ph.D.

Affiliations: 
2009 University of Rochester, Rochester, NY 
Area:
Pharmacology, Physiology Biology, Cell Biology
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Patricia M. Hinkle grad student 2009 Rochester
 (Structure of the melanocortin-2 receptor accessory protein MRAP and its roles in the regulation of melanocortin receptors trafficking and signaling.)
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Publications

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Yin TC, Mittal A, Buscaglia P, et al. (2022) Activation of Amygdala Prokineticin receptor 2 neurons drives the anorexigenic activity of the neuropeptide PK2. The Journal of Biological Chemistry. 102814
Rouault AAJ, Buscaglia P, Sebag JA. (2022) MRAP2 inhibits β-arrestin recruitment to the ghrelin receptor by preventing GHSR1a phosphorylation. The Journal of Biological Chemistry. 102057
Verdinez JA, Sebag JA. (2021) Role of N-Linked Glycosylation in PKR2 Trafficking and Signaling. Frontiers in Neuroscience. 15: 730417
Yin TC, Bauchle CJ, Rouault AAJ, et al. (2020) The Insulinostatic Effect of Ghrelin Requires MRAP2 Expression in δ Cells. Iscience. 23: 101216
Rouault AAJ, Rosselli-Murai LK, Hernandez CC, et al. (2020) The GPCR accessory protein MRAP2 regulates both biased signaling and constitutive activity of the ghrelin receptor GHSR1a. Science Signaling. 13
Perschbacher KJ, Deng G, Sandgren JA, et al. (2019) Reduced mRNA Expression of RGS2 (Regulator of G Protein Signaling-2) in the Placenta Is Associated With Human Preeclampsia and Sufficient to Cause Features of the Disorder in Mice. Hypertension (Dallas, Tex. : 1979). HYPERTENSIONAHA11914
Deng G, Sapouckey SA, Warwick CA, et al. (2018) Abstract P190: The Angiotensin AT 1A Receptor Couples to G-alpha-i inAgouti-Related Peptide-ExpressingNeurons to Control Resting Metabolic Rate Hypertension. 72
Seara F, Nakagawa P, Gomez JA, et al. (2018) Abstract 104: DOCA Induced Natriorexigenic and Hypertensive Effects are Blunted by Central Infusion of AT1 Receptor Biased Agonist TRV120027 Hypertension. 72
Srisai D, Yin TC, Lee AA, et al. (2017) MRAP2 regulates ghrelin receptor signaling and hunger sensing. Nature Communications. 8: 713
Rouault AAJ, Lee AA, Sebag JA. (2017) Regions of MRAP2 required for the inhibition of orexin and prokineticin receptor signaling. Biochimica Et Biophysica Acta
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