Benjamin F. Cravatt, PhD
Affiliations: | 1997- | Scripps Research Institute, La Jolla, La Jolla, CA, United States |
Area:
Medicinal ChemistryWebsite:
http://www.scripps.edu/research/faculty/cravattGoogle:
"Benjamin Cravatt"Bio:
Shared the Wolf Prize in Chemistry 2022 "for developing activity-based protein profiling, a chemical proteomic strategy, to characterize enzyme function in native biological systems, and describe numerous enzymes which play critical roles in human biology and disease, including the endocannabinoid hydrolases whose lipid products regulate communication between cells."
Mean distance: 16.87 | S | N | B | C | P |
Cross-listing: Neurotree
Parents
Sign in to add mentor| Dale L. Boger | grad student | 1996 | Scripps Institute | |
| (Part I. Antibody-catalyzed syn elimination reaction to form a cis olefin. Part II. The Chemistry and biology of 9(Z)-octadecenamide (Oleamide): A sleep-inducing lipid) | ||||
| Richard A. Lerner | grad student | 1996 | Scripps Institute | |
Children
Sign in to add traineeCollaborators
Sign in to add collaborator| Maurice R. Elphick | collaborator | Scripps Research Institute (Neurotree) | |
| Aron H. Lichtman | collaborator | Scripps Institute (Neurotree) |
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Publications
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| Scott KA, Kojima H, Ropek N, et al. (2023) Covalent Targeting of Splicing in T Cells. Biorxiv : the Preprint Server For Biology |
| Wichroski M, Benci J, Liu SQ, et al. (2023) DGKα/ζ inhibitors combine with PD-1 checkpoint therapy to promote T cell-mediated antitumor immunity. Science Translational Medicine. 15: eadh1892 |
| Li H, Ma T, Remsberg JR, et al. (2023) Assigning functionality to cysteines by base editing of cancer dependency genes. Nature Chemical Biology |
| Tao Y, Remillard D, Vinogradova EV, et al. (2023) Correction to "Targeted Protein Degradation by Electrophilic PROTACs that Stereoselectively and Site-Specifically Engage DCAF1". Journal of the American Chemical Society |
| Lazear MR, Remsberg JR, Jaeger MG, et al. (2023) Proteomic discovery of chemical probes that perturb protein complexes in human cells. Molecular Cell |
| Darabedian N, Ji W, Fan M, et al. (2023) Depletion of creatine phosphagen energetics with a covalent creatine kinase inhibitor. Nature Chemical Biology |
| Reed A, Ware T, Li H, et al. (2023) TMEM164 is an acyltransferase that forms ferroptotic C20:4 ether phospholipids. Nature Chemical Biology |
| Kavanagh ME, Horning BD, Khattri R, et al. (2022) Author Correction: Selective inhibitors of JAK1 targeting an isoform-restricted allosteric cysteine. Nature Chemical Biology |
| Tao Y, Remillard D, Vinogradova EV, et al. (2022) Targeted Protein Degradation by Electrophilic PROTACs that Stereoselectively and Site-Specifically Engage DCAF1. Journal of the American Chemical Society |
| Kavanagh ME, Horning BD, Khattri R, et al. (2022) Selective inhibitors of JAK1 targeting an isoform-restricted allosteric cysteine. Nature Chemical Biology |