Richard Honkanen
Affiliations: | University of South Alabama, Mobile, AL, United States |
Area:
BiochemistryGoogle:
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Children
Sign in to add trainee| Guofei Zhou | grad student | 2004 | University of South Alabama |
| Li Ni | grad student | 2006 | University of South Alabama |
| Mark Swingle | grad student | 2006 | University of South Alabama |
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Publications
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| Mayer A, Derua R, Spahn E, et al. (2024) The role of liprin-α1 phosphorylation in its liquid-liquid phase separation: regulation by PPP2R5D/PP2A holoenzyme. Biorxiv : the Preprint Server For Biology |
| Wu CG, Balakrishnan VK, Merrill RA, et al. (2023) B56δ long-disordered arms form a dynamic PP2A regulation interface coupled with global allostery and Jordan's syndrome mutations. Proceedings of the National Academy of Sciences of the United States of America. 121: e2310727120 |
| Smolen KA, Papke CM, Swingle MR, et al. (2023) Quantitative proteomics and phosphoproteomics of PP2A-PPP2R5D variants reveal deregulation of RPS6 phosphorylation via converging signaling cascades. The Journal of Biological Chemistry. 105154 |
| Salter EA, Wierzbicki A, Honkanen RE, et al. (2023) Quantum-based modeling implies that bidentate Arg-substrate binding enhances serine/threonine protein phosphatase-2A(PPP2R5D/PPP2R1A/PPP2CA)-mediated dephosphorylation. Frontiers in Cell and Developmental Biology. 11: 1141804 |
| Wu CG, Balakrishnan VK, Parihar PS, et al. (2023) Extended regulation interface coupled to the allosteric network and disease mutations in the PP2A-B56δ holoenzyme. Biorxiv : the Preprint Server For Biology |
| Shuhaibar LC, Kaci N, Egbert JR, et al. (2021) Phosphatase inhibition by LB-100 enhances BMN-111 stimulation of bone growth. Jci Insight. 6 |
| Papke CM, Smolen KA, Swingle MR, et al. (2021) A disorder-related variant (E420K) of a PP2A-regulatory subunit (PPP2R5D) causes constitutively active AKT-mTOR signaling and uncoordinated cell growth. The Journal of Biological Chemistry. 100313 |
| D'Arcy BM, Swingle MR, Schambeau L, et al. (2019) Development of a Synthetic 3-ketosteroid Δ-dehydrogenase for the Generation of a Novel Catabolic Pathway Enabling Cholesterol Degradation in Human Cells. Scientific Reports. 9: 5969 |
| D'Arcy BM, Swingle MR, Papke CM, et al. (2019) The Antitumor Drug LB-100 is a Catalytic Inhibitor of Protein Phosphatase 2A (PPP2CA) and 5 (PPP5C) Coordinating with the Catalytic Metals in the Active Site of PP5C. Molecular Cancer Therapeutics |
| Swingle MR, Honkanen RE. (2018) Inhibitors of Serine/Threonine Protein Phosphatases: Biochemical and Structural Studies Provide Insight for Further Development. Current Medicinal Chemistry |