Jason T. Fontana, Ph.D.
Affiliations: | 2002 | Yale University, New Haven, CT |
Area:
PharmacologyGoogle:
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Sign in to add mentor| William C. Sessa | grad student | 2002 | Yale | |
| (Characterization of the interaction between endothelial nitric oxide synthase and heat shock protein 90: Implications for eNOS activation and nitric oxide release.) | ||||
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| Miao RQ, Fontana J, Fulton D, et al. (2008) Dominant-negative Hsp90 reduces VEGF-stimulated nitric oxide release and migration in endothelial cells. Arteriosclerosis, Thrombosis, and Vascular Biology. 28: 105-11 |
| Fulton D, Babbitt R, Zoellner S, et al. (2004) Targeting of endothelial nitric-oxide synthase to the cytoplasmic face of the Golgi complex or plasma membrane regulates Akt- versus calcium-dependent mechanisms for nitric oxide release. The Journal of Biological Chemistry. 279: 30349-57 |
| Papapetropoulos A, Fulton D, Lin MI, et al. (2004) Vanadate is a potent activator of endothelial nitric-oxide synthase: evidence for the role of the serine/threonine kinase Akt and the 90-kDa heat shock protein. Molecular Pharmacology. 65: 407-15 |
| Ou J, Fontana JT, Ou Z, et al. (2004) Heat shock protein 90 and tyrosine kinase regulate eNOS NO* generation but not NO* bioactivity. American Journal of Physiology. Heart and Circulatory Physiology. 286: H561-9 |
| Fortugno P, Beltrami E, Plescia J, et al. (2003) Regulation of survivin function by Hsp90. Proceedings of the National Academy of Sciences of the United States of America. 100: 13791-6 |
| Pritchard KA, Ackerman AW, Ou J, et al. (2002) Native low-density lipoprotein induces endothelial nitric oxide synthase dysfunction: role of heat shock protein 90 and caveolin-1. Free Radical Biology & Medicine. 33: 52-62 |
| Fontana J, Fulton D, Chen Y, et al. (2002) Domain mapping studies reveal that the M domain of hsp90 serves as a molecular scaffold to regulate Akt-dependent phosphorylation of endothelial nitric oxide synthase and NO release. Circulation Research. 90: 866-73 |
| Fulton D, Fontana J, Sowa G, et al. (2002) Localization of endothelial nitric-oxide synthase phosphorylated on serine 1179 and nitric oxide in Golgi and plasma membrane defines the existence of two pools of active enzyme. The Journal of Biological Chemistry. 277: 4277-84 |
| Fairchild TA, Fulton D, Fontana JT, et al. (2001) Acidic hydrolysis as a mechanism for the cleavage of the Glu(298)-->Asp variant of human endothelial nitric-oxide synthase. The Journal of Biological Chemistry. 276: 26674-9 |
| Pritchard KA, Ackerman AW, Gross ER, et al. (2001) Heat shock protein 90 mediates the balance of nitric oxide and superoxide anion from endothelial nitric-oxide synthase. The Journal of Biological Chemistry. 276: 17621-4 |