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Thomas M. Guadagno

Affiliations: 
University of South Florida, Tampa, FL, United States 
Area:
Molecular Biology, Biochemistry
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"Thomas Guadagno"
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Parents

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Children

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Melinda M. Horne grad student 2004 University of South Florida
Sergiy I. Borysov grad student 2006 University of South Florida
Meghan E. Borysova grad student 2009 University of South Florida

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Publications

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Liu J, Cheng X, Zhang Y, et al. (2012) Phosphorylation of Mps1 by BRAFV600E prevents Mps1 degradation and contributes to chromosome instability in melanoma. Oncogene. 32: 713-23
Cui Y, Cheng X, Zhang C, et al. (2010) Degradation of the human mitotic checkpoint kinase Mps1 is cell cycle-regulated by APC-cCdc20 and APC-cCdh1 ubiquitin ligases. The Journal of Biological Chemistry. 285: 32988-98
Cui Y, Borysova MK, Johnson JO, et al. (2010) Oncogenic B-Raf(V600E) induces spindle abnormalities, supernumerary centrosomes, and aneuploidy in human melanocytic cells. Cancer Research. 70: 675-84
Borysova MK, Cui Y, Snyder M, et al. (2008) Knockdown of B-Raf impairs spindle formation and the mitotic checkpoint in human somatic cells. Cell Cycle (Georgetown, Tex.). 7: 2894-901
Borysov SI, Guadagno TM. (2008) A novel role for Cdk1/cyclin B in regulating B-raf activation at mitosis. Molecular Biology of the Cell. 19: 2907-15
Cui Y, Guadagno TM. (2007) B-Raf(V600E) signaling deregulates the mitotic spindle checkpoint through stabilizing Mps1 levels in melanoma cells. Oncogene. 27: 3122-33
Borysov SI, Cheng AW, Guadagno TM. (2006) B-Raf is critical for MAPK activation during mitosis and is regulated in an M phase-dependent manner in Xenopus egg extracts. The Journal of Biological Chemistry. 281: 22586-96
Guadagno TM. (2004) Too much ERK, not enough erythrocytes Blood. 104: 1591-1592
Horne MM, Guadagno TM. (2003) A requirement for MAP kinase in the assembly and maintenance of the mitotic spindle. The Journal of Cell Biology. 161: 1021-8
Guadagno TM, Ferrell JE. (1998) Requirement for MAPK activation for normal mitotic progression in Xenopus egg extracts. Science (New York, N.Y.). 282: 1312-5
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