Christopher R. Faehnle, Ph.D.

Affiliations: 
2006 The University of Toledo 
Area:
Biochemistry
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"Christopher Faehnle"
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Ronald E. Viola grad student 2006 The University of Toledo
 (Species diversity in the structure and mechanism of aspartokinase and aspartate-beta-semialdehyde dehydrogenase: Two essential enzymes in aspartate metabolism.)
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Publications

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Elkayam E, Faehnle CR, Morales M, et al. (2017) Multivalent Recruitment of Human Argonaute by GW182. Molecular Cell
Faehnle CR, Walleshauser J, Joshua-Tor L. (2017) Multi-domain utilization by TUT4 and TUT7 in control of let-7 biogenesis. Nature Structural & Molecular Biology
Naguib A, Bencze G, Cho H, et al. (2015) PTEN functions by recruitment to cytoplasmic vesicles. Molecular Cell. 58: 255-68
Faehnle CR, Walleshauser J, Joshua-Tor L. (2014) Mechanism of Dis3l2 substrate recognition in the Lin28-let-7 pathway. Nature. 514: 252-6
Faehnle CR, Elkayam E, Haase AD, et al. (2013) The Making of a Slicer: Activation of Human Argonaute-1 Cell Reports. 3: 1901-1909
Pavlovsky AG, Liu X, Faehnle CR, et al. (2012) Structural characterization of inhibitors with selectivity against members of a homologous enzyme family. Chemical Biology & Drug Design. 79: 128-36
Viola RE, Faehnle CR, Blanco J, et al. (2011) The catalytic machinery of a key enzyme in amino Acid biosynthesis. Journal of Amino Acids. 2011: 352538
Faehnle CR, Joshua-Tor L. (2010) Argonaute MID domain takes centre stage. Embo Reports. 11: 564-5
Viola RE, Liu X, Ohren JF, et al. (2008) The structure of a redundant enzyme: a second isoform of aspartate beta-semialdehyde dehydrogenase in Vibrio cholerae. Acta Crystallographica. Section D, Biological Crystallography. 64: 321-30
Faehnle CR, Joshua-Tor L. (2007) Argonautes confront new small RNAs. Current Opinion in Chemical Biology. 11: 569-77
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