Donald J. Creighton
Affiliations: | Biochemistry | University of Maryland, Baltimore County, Baltimore, MD, United States |
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Biochemistry, PharmacologyGoogle:
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Publications
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| Sang Y, Shi Q, Mo M, et al. (2015) Novel bivalent inhibitors with sub-nanomolar affinities towards human glyoxalase I. Bioorganic & Medicinal Chemistry Letters. 25: 4724-7 |
| Holewinski RJ, Creighton DJ. (2014) Inhibition by active site directed covalent modification of human glyoxalase I. Bioorganic & Medicinal Chemistry. 22: 3301-8 |
| Zheng ZB, Zhu G, Tak H, et al. (2005) N-(2-hydroxypropyl)methacrylamide copolymers of a glutathione (GSH)-activated glyoxalase i inhibitor and DNA alkylating agent: synthesis, reaction kinetics with GSH, and in vitro antitumor activities. Bioconjugate Chemistry. 16: 598-607 |
| Akoachere M, Iozef R, Rahlfs S, et al. (2005) Characterization of the glyoxalases of the malarial parasite Plasmodium falciparum and comparison with their human counterparts. Biological Chemistry. 386: 41-52 |
| Hamilton DS, Zhang X, Ding Z, et al. (2003) Mechanism of the glutathione transferase-catalyzed conversion of antitumor 2-crotonyloxymethyl-2-cycloalkenones to GSH adducts. Journal of the American Chemical Society. 125: 15049-58 |
| Zheng ZB, Creighton DJ. (2003) Bivalent transition-state analogue inhibitors of human glyoxalase I. Organic Letters. 5: 4855-8 |
| Creighton DJ, Zheng ZB, Holewinski R, et al. (2003) Glyoxalase I inhibitors in cancer chemotherapy Biochemical Society Transactions. 31: 1378-1382 |
| Joseph E, Eiseman JL, Hamilton DS, et al. (2003) Molecular basis of the antitumor activities of 2-crotonyloxymethyl-2-cycloalkenones. Journal of Medicinal Chemistry. 46: 194-6 |
| Zhang Q, Ding Z, Creighton DJ, et al. (2002) Alkylation of nucleic acids by the antitumor agent COMC. Organic Letters. 4: 1459-62 |
| Hamilton DS, Ding Z, Ganem B, et al. (2002) Glutathionyl transferase catalyzed addition of glutathione to COMC: a new hypothesis for antitumor activity. Organic Letters. 4: 1209-12 |