Namandje N. Bumpus, Ph.D.
Affiliations: | 2008 | University of Michigan, Ann Arbor, Ann Arbor, MI |
Area:
Pharmacology, BiochemistryWebsite:
https://www.hopkinsmedicine.org/profiles/results/directory/profile/0800008/namandje-bumpusGoogle:
"Namandje Bumpus"Mean distance: (not calculated yet)
Parents
Sign in to add mentor| Paul F. Hollenberg | grad student | 2008 | University of Michigan | |
| (The effects of a naturally occurring genetic polymorphism on the catalytic properties of human cytochrome P450 2B6.) | ||||
| Eric F. Johnson | post-doc | 2007-2009 | Scripps Institute | |
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Publications
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| Wheeler AM, Orsburn BC, Bumpus NN. (2023) Biotransformation of efavirenz and proteomic analysis of P450s and UGTs in mouse, macaque, and human brain-derived systems. Drug Metabolism and Disposition: the Biological Fate of Chemicals |
| McGuire MR, Mukhopadhyay D, Myers SL, et al. (2021) Progesterone receptor membrane component 1 (PGRMC1) binds and stabilizes cytochromes P450 through a heme-independent mechanism. The Journal of Biological Chemistry. 101316 |
| Heck CJS, Seneviratne HK, Bumpus NN. (2020) Twelfth-Position Deuteration of Nevirapine Reduces 12-Hydroxy-Nevirapine Formation and Nevirapine-Induced Hepatocyte Death. Journal of Medicinal Chemistry |
| McGuire MR, Mosher E, Myers S, et al. (2020) PGRMC1 Stabilizes Cytochromes P450 And Is Required for Activity In Vivo The Faseb Journal. 34: 1-1 |
| Cox PM, Bumpus NN. (2016) Single Heteroatom Substitutions in the Efavirenz Oxazinone Ring Impact Metabolism by CYP2B6. Chemmedchem |
| Cox PM, Bumpus NN. (2014) Structure-Activity Studies Reveal the Oxazinone Ring Is a Determinant of Cytochrome P450 2B6 Activity Toward Efavirenz. Acs Medicinal Chemistry Letters. 5: 1156-1161 |
| Hersman EM, Bumpus NN. (2014) A targeted proteomics approach for profiling murine cytochrome P450 expression. The Journal of Pharmacology and Experimental Therapeutics. 349: 221-8 |
| Lu Y, Hendrix CW, Bumpus NN. (2012) Cytochrome P450 3A5 plays a prominent role in the oxidative metabolism of the anti-human immunodeficiency virus drug maraviroc. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 40: 2221-30 |
| Yanakakis LJ, Bumpus NN. (2012) Biotransformation of the antiretroviral drug etravirine: metabolite identification, reaction phenotyping, and characterization of autoinduction of cytochrome P450-dependent metabolism. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 40: 803-14 |
| Bumpus NN, Johnson EF. (2011) 5-Aminoimidazole-4-carboxyamide-ribonucleoside (AICAR)-stimulated hepatic expression of Cyp4a10, Cyp4a14, Cyp4a31, and other peroxisome proliferator-activated receptor α-responsive mouse genes is AICAR 5'-monophosphate-dependent and AMP-activated protein kinase-independent. The Journal of Pharmacology and Experimental Therapeutics. 339: 886-95 |