Karlo M. Lopez, Ph.D.

Affiliations: 
2007 Clark University, Worcester, MA, United States 
Area:
Biochemistry
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Frederick T. Greenaway grad student 2007 Clark University
 (Cloning, overexpression, and characterization of human aorta lysyl oxidase: Characterization of the copper -binding site by site-directed mutagenesis of histidine residues.)
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Publications

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Oldfield RN, Johnston KA, Limones J, et al. (2017) Identification of Histidine 303 as the Catalytic Base of Lysyl Oxidase via Site-Directed Mutagenesis. The Protein Journal
Smith MA, Gonzalez J, Hussain A, et al. (2016) Overexpression of Soluble Recombinant Human Lysyl Oxidase by Using Solubility Tags: Effects on Activity and Solubility. Enzyme Research. 2016: 5098985
Herwald S, Liu AY, Zhu BE, et al. (2013) Structure and substrate specificity of the pyrococcal coenzyme A disulfide reductases/polysulfide reductases (CoADR/Psr): implications for S(0)-based respiration and a sulfur-dependent antioxidant system in Pyrococcus. Biochemistry. 52: 2764-73
Lopez KM, Greenaway FT. (2011) Identification of the copper-binding ligands of lysyl oxidase. Journal of Neural Transmission (Vienna, Austria : 1996). 118: 1101-9
Warner MD, Lukose V, Lee KH, et al. (2011) Characterization of an NADH-Dependent Persulfide Reductase from Shewanella loihica PV-4: Implications for the Mechanism of Sulfur Respiration via FAD-Dependent Enzymes . Biochemistry. 50: 194-206
Herwald SE, Greenaway FT, Lopez KM. (2010) Purification of high yields of catalytically active lysyl oxidase directly from Escherichia coli cell culture. Protein Expression and Purification. 74: 116-21
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