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John A. Means, Ph.D.

Affiliations: 
2007 Department of Chemistry and Biochemistry Ohio University, Athens, OH, United States 
Area:
Biochemistry
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Jennifer V. Hines grad student 2007 Ohio University
 (Fluorescence and NMR characterization of a T box antiterminator-tRNA complex.)

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Mitchell MO, Means J. (2018) Cation−Π Interactions in Biochemistry: A Primer Journal of Chemical Education. 95: 2284-2288
Liu J, Zeng C, Zhou S, et al. (2015) Fluorescence assays for monitoring RNA-ligand interactions and riboswitch-targeted drug discovery screening. Methods in Enzymology. 550: 363-83
Zhou S, Means JA, Acquaah-Harrison G, et al. (2012) Characterization of a 1,4-disubstituted 1,2,3-triazole binding to T box antiterminator RNA. Bioorganic & Medicinal Chemistry. 20: 1298-302
Orac CM, Zhou S, Means JA, et al. (2011) Synthesis and stereospecificity of 4,5-disubstituted oxazolidinone ligands binding to T-box riboswitch RNA. Journal of Medicinal Chemistry. 54: 6786-95
Hines J, Means JA, Muchenditsi A, et al. (2010) Structural Probing of the T Box Antiterminator-tRNA Complex Biophysical Journal. 98: 263a
Means JA, Simson CM, Zhou S, et al. (2009) Fluorescence probing of T box antiterminator RNA: insights into riboswitch discernment of the tRNA discriminator base. Biochemical and Biophysical Research Communications. 389: 616-21
Anupam R, Nayek A, Green NJ, et al. (2008) 4,5-Disubstituted oxazolidinones: High affinity molecular effectors of RNA function. Bioorganic & Medicinal Chemistry Letters. 18: 3541-4
Jack KD, Means JA, Hines JV. (2008) Characterizing riboswitch function: identification of Mg2+ binding site in T box antiterminator RNA. Biochemical and Biophysical Research Communications. 370: 306-10
Means JA, Wolf S, Agyeman A, et al. (2007) T box riboswitch antiterminator affinity modulated by tRNA structural elements. Chemical Biology & Drug Design. 69: 139-45
Means J, Katz S, Nayek A, et al. (2006) Structure-activity studies of oxazolidinone analogs as RNA-binding agents. Bioorganic & Medicinal Chemistry Letters. 16: 3600-4
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