Lauren A. Seiple, Ph.D.
Affiliations: | 2008 | Johns Hopkins University, Baltimore, MD |
Area:
PharmacologyGoogle:
"Lauren Seiple"Mean distance: (not calculated yet)
Parents
Sign in to add mentor| James T. Stivers | grad student | 2008 | Johns Hopkins | |
| (Uracil base excision repair as a therapeutic target.) | ||||
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Publications
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| Weil AF, Ghosh D, Zhou Y, et al. (2013) Uracil DNA glycosylase initiates degradation of HIV-1 cDNA containing misincorporated dUTP and prevents viral integration. Proceedings of the National Academy of Sciences of the United States of America. 110: E448-57 |
| Seiple LA, Cardellina JH, Akee R, et al. (2008) Potent inhibition of human apurinic/apyrimidinic endonuclease 1 by arylstibonic acids. Molecular Pharmacology. 73: 669-77 |
| Krosky DJ, Bianchet MA, Seiple L, et al. (2006) Mimicking damaged DNA with a small molecule inhibitor of human UNG2. Nucleic Acids Research. 34: 5872-9 |
| Seiple L, Jaruga P, Dizdaroglu M, et al. (2006) Linking uracil base excision repair and 5-fluorouracil toxicity in yeast. Nucleic Acids Research. 34: 140-51 |
| Jiang YL, Krosky DJ, Seiple L, et al. (2005) Uracil-directed ligand tethering: an efficient strategy for uracil DNA glycosylase (UNG) inhibitor development. Journal of the American Chemical Society. 127: 17412-20 |
| Bianchet MA, Seiple LA, Jiang YL, et al. (2003) Electrostatic guidance of glycosyl cation migration along the reaction coordinate of uracil DNA glycosylase. Biochemistry. 42: 12455-60 |