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Yury J. Sigal, Ph.D.

Affiliations: 
2007 Cell & Developmental Biology University of North Carolina, Chapel Hill, Chapel Hill, NC 
Area:
Cell Biology, Biochemistry
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Vytas A. Bankaitis grad student 2007 UNC Chapel Hill
 (Lipid phosphatases and related proteins: From regulation of phospholipid metabolism to filopodia formation.)

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Publications

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Loitto VM, Huang C, Sigal YJ, et al. (2007) Filopodia are induced by aquaporin-9 expression. Experimental Cell Research. 313: 1295-306
Sigal YJ, Quintero OA, Cheney RE, et al. (2007) Cdc42 and ARP2/3-independent regulation of filopodia by an integral membrane lipid-phosphatase-related protein. Journal of Cell Science. 120: 340-52
McDermott MI, Sigal YJ, Crump JS, et al. (2006) Enzymatic analysis of lipid phosphate phosphatases. Methods (San Diego, Calif.). 39: 169-79
Sigal YJ, McDermott MI, Morris AJ. (2005) Integral membrane lipid phosphatases/phosphotransferases: common structure and diverse functions. The Biochemical Journal. 387: 281-93
Renault AD, Sigal YJ, Morris AJ, et al. (2004) Soma-germ line competition for lipid phosphate uptake regulates germ cell migration and survival Science. 305: 1963-1966
Smyth SS, Sciorra VA, Sigal YJ, et al. (2003) Lipid phosphate phosphatases regulate lysophosphatidic acid production and signaling in platelets: studies using chemical inhibitors of lipid phosphate phosphatase activity. The Journal of Biological Chemistry. 278: 43214-23
Tanyi JL, Morris AJ, Wolf JK, et al. (2003) The human lipid phosphate phosphatase-3 decreases the growth, survival, and tumorigenesis of ovarian cancer cells: validation of the lysophosphatidic acid signaling cascade as a target for therapy in ovarian cancer. Cancer Research. 63: 1073-82
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