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Patrick J. Burke, Ph.D.

Affiliations: 
2003 University of Colorado, Boulder, Boulder, CO, United States 
Area:
Organic Chemistry
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Tad Harbison Koch grad student 2003 CU Boulder
 (Design, synthesis, and biological evaluation of doxorubicin-formaldehyde conjugates targeted to breast cancer cells.)

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Hamilton JZ, Pires TA, Mitchell JA, et al. (2020) Improving Antibody-Tubulysin Conjugates Through Linker Chemistry and Site-Specific Conjugation. Chemmedchem
Burke PJ, Hamilton JZ, Pires TA, et al. (2018) Glucuronide-linked antibody-tubulysin conjugates display activity in MDR+ and heterogeneous tumor models. Molecular Cancer Therapeutics
Kung Sutherland MS, Walter RB, Jeffrey SC, et al. (2013) SGN-CD33A: a novel CD33-targeting antibody-drug conjugate using a pyrrolobenzodiazepine dimer is active in models of drug-resistant AML. Blood. 122: 1455-63
Burke PJ, Senter PD, Meyer DW, et al. (2009) Design, synthesis, and biological evaluation of antibody-drug conjugates comprised of potent camptothecin analogues. Bioconjugate Chemistry. 20: 1242-50
Burke PJ, Toki BE, Meyer DW, et al. (2009) Novel immunoconjugates comprised of streptonigrin and 17-amino-geldanamycin attached via a dipeptide-p-aminobenzyl-amine linker system. Bioorganic & Medicinal Chemistry Letters. 19: 2650-3
Burke PJ, Kalet BT, Koch TH. (2004) Antiestrogen binding site and estrogen receptor mediate uptake and distribution of 4-hydroxytamoxifen-targeted doxorubicin-formaldehyde conjugate in breast cancer cells. Journal of Medicinal Chemistry. 47: 6509-18
Burke PJ, Koch TH. (2004) Design, synthesis, and biological evaluation of doxorubicin-formaldehyde conjugates targeted to breast cancer cells. Journal of Medicinal Chemistry. 47: 1193-206
Itharat A, Houghton PJ, Eno-Amooquaye E, et al. (2004) In vitro cytotoxic activity of Thai medicinal plants used traditionally to treat cancer Journal of Ethnopharmacology. 90: 33-38
Burke PJ, Koch TH. (2001) Doxorubicin-formaldehyde conjugate, doxoform: induction of apoptosis relative to doxorubicin. Anticancer Research. 21: 2753-60
Kato S, Burke PJ, Koch TH, et al. (2001) Formaldehyde in human cancer cells: detection by preconcentration-chemical ionization mass spectrometry. Analytical Chemistry. 73: 2992-7
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