Michael J. Emanuele, Ph.D.
Affiliations: | 2007 | University of Virginia, Charlottesville, VA | |
| 2013- | Pharmacology | University of North Carolina, Chapel Hill, Chapel Hill, NC |
Area:
cell cycle, mitosis, protein stability, ubiquitin, cancer, genetics, cell biologyWebsite:
https://www.med.unc.edu/pharm/people/primaryfaculty/michael-j.-emanueleGoogle:
"Michael J. Emanuele"Bio:
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Parents
Sign in to add mentor| Peter Todd Stukenberg | grad student | 2007 | UVA | |
| (Biochemical and functional analysis of the vertebrate kinetochore.) | ||||
| Stephen J. Elledge | post-doc | 2013 | Harvard Medical School | |
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Publications
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| Mouery RD, Hsu C, Bonacci T, et al. (2023) Proteomic Analysis Reveals a PLK1-Dependent G2/M Degradation Program and Links PKA-AKAP2 to Cell Cycle Control. Biorxiv : the Preprint Server For Biology |
| Enrico TP, Stallaert W, Wick ET, et al. (2021) Cyclin F drives proliferation through SCF-dependent degradation of the retinoblastoma-like tumor suppressor p130/RBL2. Elife. 10 |
| Wasserman D, Nachum S, Noach-Hirsh M, et al. (2021) Elucidating Human Mitosis Using an Anaphase-Like Cell-Free System. Methods in Molecular Biology (Clifton, N.J.). 2329: 143-164 |
| Franks JL, Martinez-Chacin RC, Wang X, et al. (2020) In silico APC/C substrate discovery reveals cell cycle-dependent degradation of UHRF1 and other chromatin regulators. Plos Biology. 18: e3000975 |
| Emanuele MJ, Enrico TP, Mouery RD, et al. (2020) Complex Cartography: Regulation of E2F Transcription Factors by Cyclin F and Ubiquitin. Trends in Cell Biology |
| Martinez-Chacin RC, Bodrug T, Bolhuis DL, et al. (2020) Ubiquitin chain-elongating enzyme UBE2S activates the RING E3 ligase APC/C for substrate priming. Nature Structural & Molecular Biology |
| Bonacci T, Emanuele MJ. (2020) Dissenting degradation: Deubiquitinases in cell cycle and cancer. Seminars in Cancer Biology |
| Wasserman D, Nachum S, Cohen M, et al. (2020) Cell cycle oscillators underlying orderly proteolysis of E2F8. Molecular Biology of the Cell. mbcE19120725 |
| McDonald IM, Grant GD, East MP, et al. (2020) Mass spectrometry-based selectivity profiling identifies a highly selective inhibitor of the kinase MELK that delays mitotic entry in cancer cells. The Journal of Biological Chemistry |
| Blake DR, Vaseva AV, Hodge RG, et al. (2019) Application of a MYC degradation screen identifies sensitivity to CDK9 inhibitors in KRAS-mutant pancreatic cancer. Science Signaling. 12 |