Hilary Frase, Ph.D.
Affiliations: | 2007 | Case Western Reserve University, Cleveland Heights, OH, United States |
Area:
BiochemistryGoogle:
"Hilary Frase"Mean distance: (not calculated yet)
Parents
Sign in to add mentor| Irene Lee | grad student | 2007 | Case Western | |
| (Towards developing specific inhibitors of the ATP-dependent Lon protease.) | ||||
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Publications
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| Smith CA, Antunes NT, Stewart NK, et al. (2015) Structural Basis for Enhancement of Carbapenemase Activity in the OXA-51 Family of Class D β-Lactamases. Acs Chemical Biology |
| Stewart NK, Smith CA, Frase H, et al. (2015) Kinetic and structural requirements for carbapenemase activity in GES-type β-lactamases. Biochemistry. 54: 588-97 |
| Smith CA, Toth M, Weiss TM, et al. (2014) Structure of the bifunctional aminoglycoside-resistance enzyme AAC(6')-Ie-APH(2'')-Ia revealed by crystallographic and small-angle X-ray scattering analysis. Acta Crystallographica. Section D, Biological Crystallography. 70: 2754-64 |
| Smith CA, Toth M, Bhattacharya M, et al. (2014) Structure of the phosphotransferase domain of the bifunctional aminoglycoside-resistance enzyme AAC(6')-Ie-APH(2'')-Ia. Acta Crystallographica. Section D, Biological Crystallography. 70: 1561-71 |
| Toth M, Frase H, Antunes NT, et al. (2013) Novel aminoglycoside 2''-phosphotransferase identified in a gram-negative pathogen. Antimicrobial Agents and Chemotherapy. 57: 452-7 |
| Frase H, Toth M, Vakulenko SB. (2012) Revisiting the nucleotide and aminoglycoside substrate specificity of the bifunctional aminoglycoside acetyltransferase(6')-Ie/aminoglycoside phosphotransferase(2'')-Ia enzyme. The Journal of Biological Chemistry. 287: 43262-9 |
| Cheng I, Mikita N, Fishovitz J, et al. (2012) Identification of a region in the N-terminus of Escherichia coli Lon that affects ATPase, substrate translocation and proteolytic activity. Journal of Molecular Biology. 418: 208-25 |
| Smith CA, Toth M, Frase H, et al. (2012) Aminoglycoside 2''-phosphotransferase IIIa (APH(2'')-IIIa) prefers GTP over ATP: structural templates for nucleotide recognition in the bacterial aminoglycoside-2'' kinases. The Journal of Biological Chemistry. 287: 12893-903 |
| Fishovitz J, Li M, Frase H, et al. (2011) Active-site-directed chemical tools for profiling mitochondrial Lon protease. Acs Chemical Biology. 6: 781-8 |
| Frase H, Smith CA, Toth M, et al. (2011) Identification of products of inhibition of GES-2 beta-lactamase by tazobactam by x-ray crystallography and spectrometry. The Journal of Biological Chemistry. 286: 14396-409 |