Mark K. Schlegel, Ph.D.
Affiliations: | 2009 | University of Pennsylvania, Philadelphia, PA, United States |
Area:
Organic Chemistry, BiochemistryGoogle:
"Mark Schlegel"Mean distance: (not calculated yet)
Parents
Sign in to add mentor| Eric Meggers | grad student | 2005-2009 | Penn | |
| (The synthesis and characterization of glycol nucleic acids.) | ||||
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Publications
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| Egli M, Schlegel MK, Manoharan M. (2023) Acyclic (S)-Glycol Nucleic Acid (S-GNA) Modification of siRNAs Improves the Safety of RNAi Therapeutics While Maintaining Potency. Rna (New York, N.Y.) |
| Schlegel MK, Foster DJ, Kel'in AV, et al. (2017) Chirality Dependent Potency Enhancement and Structural Impact of Glycol Nucleic Acid Modification on siRNA. Journal of the American Chemical Society |
| Hahm HS, Schlegel MK, Hurevich M, et al. (2017) Automated glycan assembly using the Glyconeer 2.1 synthesizer. Proceedings of the National Academy of Sciences of the United States of America |
| Yu H, Schlegel MK, McLaughlin LW. (2014) The synthesis and structural characterization of both diastereomers of 5′-(hydroxymethyl)-6,5′-cyclo-2′,5′-dideoxyuridine cyclonucleosides Rsc Advances. 4: 32588-32593 |
| Yueh H, Pal A, Chang K, et al. (2013) Synthesis and NMR assignment of the two diastereomers of 8,6′-Cyclo-2′,6′-Dideoxyadenosine Nucleosides, Nucleotides and Nucleic Acids. 32: 320-332 |
| Doknic D, Abramo M, Sutkeviciute I, et al. (2013) Synthesis and characterization of linker-armed fucose-based glycomimetics European Journal of Organic Chemistry. 5303-5314 |
| Schlegel MK, Hütter J, Eriksson M, et al. (2011) Defined presentation of carbohydrates on a duplex DNA scaffold. Chembiochem : a European Journal of Chemical Biology. 12: 2791-800 |
| Johnson AT, Schlegel MK, Meggers E, et al. (2011) On the structure and dynamics of duplex GNA. The Journal of Organic Chemistry. 76: 7964-74 |
| Schlegel MK, Essen LO, Meggers E. (2010) Atomic resolution duplex structure of the simplified nucleic acid GNA. Chemical Communications (Cambridge, England). 46: 1094-6 |
| Schlegel MK, Meggers E. (2009) Improved phosphoramidite building blocks for the synthesis of the simplified nucleic acid GNA. The Journal of Organic Chemistry. 74: 4615-8 |