Fatbardha Varfaj, Ph.D.

Affiliations: 
2007 University of Rochester, Rochester, NY 
Area:
Biochemistry
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"Fatbardha Varfaj"
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Philip J. Fay grad student 2007 Rochester
 (Contributions of exosite interactions and active site docking to activated protein C-catalyzed inactivation of factor VIIIa.)
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Publications

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DeAngelis JP, Varfaj F, Wakabayashi H, et al. (2011) The role of P4-P3' residues flanking Arg336 in facilitating activated protein C-catalyzed cleavage and inactivation of factor VIIIa. Thrombosis Research. 128: 470-6
Wakabayashi H, Varfaj F, Deangelis J, et al. (2008) Generation of enhanced stability factor VIII variants by replacement of charged residues at the A2 domain interface. Blood. 112: 2761-9
Varfaj F, Wakabayashi H, Fay PJ. (2007) Residues surrounding Arg336 and Arg562 contribute to the disparate rates of proteolysis of factor VIIIa catalyzed by activated protein C. The Journal of Biological Chemistry. 282: 20264-72
Wakabayashi H, Zhou Q, Varfaj F, et al. (2007) A3 domain residue Glu1829 contributes to A2 subunit retention in factor VIIIa. Journal of Thrombosis and Haemostasis : Jth. 5: 996-1001
Varfaj F, Wakabayashi H, Fay PJ. (2007) The Mutation Leu335Pro in Factor VIII Results in Its Rapid Inactivation by Thrombin-Catalyzed Proteolysis at Arg336. Blood. 110: 2690-2690
Varfaj F, DeAngelis J, Wakabayashi H, et al. (2007) P2 and P2′ Residues Are Important for the Efficient Proteolysis of Factor VIIIa at Arg336 Catalyzed by Activated Protein C. Blood. 110: 2689-2689
Varfaj F, Wakabayashi H, Fay P. (2007) LEU335 CONTRIBUTES TO THE EFFICIENT PROTEOLYSIS OF FACTOR VIIIA AT ARG336 CATALYZED BY ACTIVATED PROTEIN C Journal of Thrombosis and Haemostasis. 5: P-S-038-P-S-038
Wakabayashi H, Zhou Q, Nogami K, et al. (2006) pH-dependent association of factor VIII chains: enhancement of affinity at physiological pH by Cu2+. Biochimica Et Biophysica Acta. 1764: 1094-101
Varfaj F, Neuberg J, Jenkins PV, et al. (2006) Role of P1 residues Arg336 and Arg562 in the activated-Protein-C-catalysed inactivation of Factor VIIIa. The Biochemical Journal. 396: 355-62
Varfaj F, Wakabayashi H, Fay PJ. (2006) Contribution of P4-P3′ Residues Surrounding P1 Residues Arg336 and Arg562 in the Activated Protein C-Catalyzed Inactivation of Factor VIIIa. Blood. 108: 1693-1693
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