Summer M. Raines, Ph.D.

Affiliations: 
2010 University of Wisconsin, Madison, Madison, WI 
Area:
Biochemistry, Animal Physiology Biology, Nutrition
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Alan D. Attie grad student 2010 UW Madison
 (The role of platelet-derived growth factor-B (PDGF-B) and sortilin-relatred receptor central nervous system expressed 1 (SorCS1) in vascular integrity and maintenance of peripheral insulin sensitivity.)
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Publications

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Kebede MA, Oler AT, Gregg T, et al. (2014) SORCS1 is necessary for normal insulin secretory granule biogenesis in metabolically stressed β cells. The Journal of Clinical Investigation. 124: 4240-56
Raines SM, Richards OC, Schneider LR, et al. (2011) Loss of PDGF-B activity increases hepatic vascular permeability and enhances insulin sensitivity. American Journal of Physiology. Endocrinology and Metabolism. 301: E517-26
Lane RF, Raines SM, Steele JW, et al. (2010) Diabetes-associated SorCS1 regulates Alzheimer's amyloid-beta metabolism: evidence for involvement of SorL1 and the retromer complex. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 13110-5
Richards OC, Raines SM, Attie AD. (2010) The role of blood vessels, endothelial cells, and vascular pericytes in insulin secretion and peripheral insulin action. Endocrine Reviews. 31: 343-63
Lane RF, Raines SM, Levey A, et al. (2010) Diabetes-linked SORCS1, a gamma-secretase substrate and regulator of Alzheimer APP metabolism, forms complexes with multiple Alzheimer-linked proteins (APP, PS1, BACE, VPS35, and SORLA) Alzheimers & Dementia. 6
Clee SM, Yandell BS, Schueler KM, et al. (2006) Positional cloning of Sorcs1, a type 2 diabetes quantitative trait locus. Nature Genetics. 38: 688-93
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