Longqin Hu, Ph.D.

Affiliations: 
1999- Medicinal Chemistry Rutgers University, New Brunswick, New Brunswick, NJ, United States 
Area:
Medicinal Chemistry
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"Longqin Hu"
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Publications

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Lee S, Ali AR, Abed DA, et al. (2023) Structural modification of C2-substituents on 1,4-bis(arylsulfonamido)benzene or naphthalene-N,N'-diacetic acid derivatives as potent inhibitors of the Keap1-Nrf2 protein-protein interaction. European Journal of Medicinal Chemistry. 265: 116104
Yang J, Albanyan H, Wang Y, et al. (2023) Development of convenient crystallization inhibition assays for structure-activity relationship studies in the discovery of crystallization inhibitors. Medicinal Chemistry Research : An International Journal For Rapid Communications On Design and Mechanisms of Action of Biologically Active Agents. 32: 1391-1399
Abed DA, Ali AR, Lee S, et al. (2023) Optimization of the C2 substituents on the 1,4-bis(arylsulfonamido)naphthalene-N,N'-diacetic acid scaffold for better inhibition of Keap1-Nrf2 protein-protein interaction. European Journal of Medicinal Chemistry. 252: 115302
Lee S, Abed DA, Nguyen MU, et al. (2022) Structure-activity relationships of 1,4-bis(arylsulfonamido)-benzene or naphthalene-N,N'-diacetic acids with varying C2-substituents as inhibitors of Keap1-Nrf2 protein-protein interaction. European Journal of Medicinal Chemistry. 237: 114380
Abed DA, Lee S, Wen X, et al. (2021) Optimization of 1,4-bis(arylsulfonamido)naphthalene-N,N'-diacetic acids as inhibitors of Keap1-Nrf2 protein-protein interaction to suppress neuroinflammation. Bioorganic & Medicinal Chemistry. 44: 116300
Lee S, Abed DA, Beamer LJ, et al. (2020) Development of a Homogeneous Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) Assay for the Inhibition of Keap1-Nrf2 Protein-Protein Interaction. Slas Discovery : Advancing Life Sciences R & D. 2472555220935816
Lee S, Hu L. (2020) Nrf2 activation through the inhibition of Keap1-Nrf2 protein-protein interaction. Medicinal Chemistry Research : An International Journal For Rapid Communications On Design and Mechanisms of Action of Biologically Active Agents. 29: 846-867
Abed DA, Lee S, Hu L. (2020) Discovery of disubstituted xylylene derivatives as small molecule direct inhibitors of Keap1-Nrf2 protein-protein interaction. Bioorganic & Medicinal Chemistry. 115343
Aloysius H, Hu L. (2020) Synthesis and evaluation of new peptide-linked doxorubicin conjugates as prodrugs activated by prostate-specific antigen Medicinal Chemistry Research. 29: 1280-1299
Aloysius H, Hu L. (2020) Synthesis and evaluation of new 4-peptidamido-2-fluorobenzyl phosphoramide mustard conjugates as prodrugs activated by prostate-specific antigen Medicinal Chemistry Research. 29: 1264-1279
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