Gary E. Isom
Affiliations: | Medicinal Chemistry and Molecular Pharmacology | Purdue University, West Lafayette, IN, United States |
Area:
ToxicologyWebsite:
https://www.mcmp.purdue.edu/faculty/geisomGoogle:
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Parents
Sign in to add mentor| James L. Way | grad student | 1973 | WSU | |
| (Some aspects of cyanide intoxication and its antagonism.) | ||||
Children
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Publications
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| Lee J, Kim JG, Mahon SB, et al. (2014) Noninvasive optical cytochrome c oxidase redox state measurements using diffuse optical spectroscopy. Journal of Biomedical Optics. 19: 055001 |
| Leavesley HB, Li L, Mukhopadhyay S, et al. (2010) Nitrite-mediated antagonism of cyanide inhibition of cytochrome c oxidase in dopamine neurons. Toxicological Sciences : An Official Journal of the Society of Toxicology. 115: 569-76 |
| Zhang L, Li L, Leavesley HW, et al. (2010) Cyanide-induced apoptosis of dopaminergic cells is promoted by BNIP3 and Bax modulation of endoplasmic reticulum-mitochondrial Ca2+ levels. The Journal of Pharmacology and Experimental Therapeutics. 332: 97-105 |
| Zhang L, Li L, Liu H, et al. (2009) BNIP3 mediates cell death by different pathways following localization to endoplasmic reticulum and mitochondrion. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 23: 3405-14 |
| Zhang X, Li L, Zhang L, et al. (2009) Cyanide-induced death of dopaminergic cells is mediated by uncoupling protein-2 up-regulation and reduced Bcl-2 expression. Toxicology and Applied Pharmacology. 238: 11-9 |
| Li L, Prabhakaran K, Zhang X, et al. (2008) 1Alpha,25-dihydroxyvitamin D3 attenuates cyanide-induced neurotoxicity by inhibiting uncoupling protein-2 up-regulation. Journal of Neuroscience Research. 86: 1397-408 |
| Leavesley HB, Li L, Prabhakaran K, et al. (2008) Interaction of cyanide and nitric oxide with cytochrome c oxidase: implications for acute cyanide toxicity. Toxicological Sciences : An Official Journal of the Society of Toxicology. 101: 101-11 |
| Prabhakaran K, Li L, Zhang L, et al. (2007) Upregulation of BNIP3 and translocation to mitochondria mediates cyanide-induced apoptosis in cortical cells Neuroscience. 150: 159-167 |
| Zhang X, Li L, Prabhakaran K, et al. (2007) Uncoupling protein-2 up-regulation and enhanced cyanide toxicity are mediated by PPARalpha activation and oxidative stress. Toxicology and Applied Pharmacology. 223: 10-9 |
| Zhang L, Li L, Liu H, et al. (2007) HIF-1alpha activation by a redox-sensitive pathway mediates cyanide-induced BNIP3 upregulation and mitochondrial-dependent cell death. Free Radical Biology & Medicine. 43: 117-27 |