Harsh V. Jain, Ph.D.

Affiliations: 
2010 Chemistry State University of New York, Buffalo, Buffalo, NY, United States 
Area:
Organic Chemistry, Biochemistry, Pharmaceutical Chemistry
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Thomas I. Kalman grad student 2010 SUNY Buffalo
 (I:- Design, synthesis and study of nucleotide prodrugs. II:- Synthesis of 5-fluoro-6-[(2-aminoimidazol-1-yl)methyl]uracil (AIFU) and study of its mechanism of action as a thymidine phosphorylase inhibitor. III:- Design and synthesis of novel nucleotide an)
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Publications

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Jain HV, Boehler JF, Nagaraju K, et al. (2018) Synthesis, Characterization, and Function of an RNA-Based Transfection Reagent. Current Protocols in Nucleic Acid Chemistry. 72: 4.81.1-4.81.29
Hsu CJ, Jain HV, Williams A, et al. (2017) Trans-acting oligodeoxythymidine phosphorothioate triester reagents for transient transfection optimized and facilitated by a high-throughput microbioreactor system. Biotechnology and Applied Biochemistry
Jain HV, Boehler JF, Verthelyi D, et al. (2017) An amphipathic trans-acting phosphorothioate RNA element delivers an uncharged phosphorodiamidate morpholino sequence in mdx mouse myotubes. Rsc Advances. 7: 42519-42528
Jain HV, Beaucage SL. (2016) An amphipathic trans-acting phosphorothioate DNA element delivers uncharged PNA and PMO nucleic acid sequences in mammalian cells. Current Protocols in Nucleic Acid Chemistry / Edited by Serge L. Beaucage ... [Et Al.]. 64: 4.69.1-4.69.22
Jain HV, Verthelyi D, Beaucage SL. (2015) Amphipathic trans-acting phosphorothioate DNA elements mediate the delivery of uncharged nucleic acid sequences in mammalian cells Rsc Advances. 5: 65245-65254
Jain HV, Takeda K, Tami C, et al. (2013) Assessment of the cellular internalization of thermolytic phosphorothioate DNA oligonucleotide prodrugs. Bioorganic & Medicinal Chemistry. 21: 6224-32
Jain HV, Kalman TI. (2012) Synthesis and study of cyclic pronucleotides of 5-fluoro-2'-deoxyuridine. Bioorganic & Medicinal Chemistry Letters. 22: 4497-501
Jain HV, Rasheed R, Kalman TI. (2010) The role of phosphate in the action of thymidine phosphorylase inhibitors: Implications for the catalytic mechanism. Bioorganic & Medicinal Chemistry Letters. 20: 1648-51
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