Neil R. McIntyre, Ph.D.
Affiliations: | 2008 | University of South Florida, Tampa, FL, United States |
Area:
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Parents
Sign in to add mentor| David J. Merkler | grad student | 2008 | University of South Florida | |
| (Mechanistic studies of peptidylglycine alpha -amidating monooxygenase (PAM).) | ||||
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Publications
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| McIntyre NR, Lowe EW, Battistini MR, et al. (2015) Inactivation of peptidylglycine α-hydroxylating monooxygenase by cinnamic acid analogs. Journal of Enzyme Inhibition and Medicinal Chemistry. 1-12 |
| McIntyre NR, Franco R, Shelnutt JA, et al. (2011) Nickel(II) chelatase variants directly evolved from murine ferrochelatase: porphyrin distortion and kinetic mechanism. Biochemistry. 50: 1535-44 |
| McIntyre NR, Lowe EW, Belof JL, et al. (2010) Evidence for substrate preorganization in the peptidylglycine α-amidating monooxygenase reaction describing the contribution of ground state structure to hydrogen tunneling. Journal of the American Chemical Society. 132: 16393-402 |
| McIntyre NR, Lowe EW, Merkler DJ. (2009) Imino-oxy acetic acid dealkylation as evidence for an inner-sphere alcohol intermediate in the reaction catalyzed by peptidylglycine alpha-hydroxylating monooxygenase. Journal of the American Chemical Society. 131: 10308-19 |
| Merkler DJ, Asser AS, Baumgart LE, et al. (2008) Substituted hippurates and hippurate analogs as substrates and inhibitors of peptidylglycine alpha-hydroxylating monooxygenase (PHM). Bioorganic & Medicinal Chemistry. 16: 10061-74 |
| Weiss ST, McIntyre NR, McLaughlin ML, et al. (2006) The development of molecular clamps as drugs. Drug Discovery Today. 11: 819-24 |
| McIntyre NR, Lowe EW, Chew GH, et al. (2006) Thiorphan, tiopronin, and related analogs as substrates and inhibitors of peptidylglycine alpha-amidating monooxygenase (PAM). Febs Letters. 580: 521-32 |
| Chew GH, Galloway LC, McIntyre NR, et al. (2005) Ubiquitin and ubiquitin-derived peptides as substrates for peptidylglycine alpha-amidating monooxygenase. Febs Letters. 579: 4678-84 |