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Prakash Manikwar, Ph.D.

Affiliations: 
2010 Pharmaceutical Chemistry University of Kansas, Lawrence, KS, United States 
Area:
Pharmaceutical Chemistry
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Teruna J. Siahaan grad student 2010 University of Kansas
 (In vitro and in vivo evaluation of novel I-domain conjugates for drug targeting to immune cells and suppression of EAE in mice.)

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Publications

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Manikwar P, Raju Mulagapati SH, Kasturirangan S, et al. (2019) Characterization of a Novel Bispecific Antibody with Improved Conformational and Chemical Stability. Journal of Pharmaceutical Sciences
Manikwar P, Majumdar R, Hickey JM, et al. (2013) Correlating excipient effects on conformational and storage stability of an IgG1 monoclonal antibody with local dynamics as measured by hydrogen/deuterium-exchange mass spectrometry. Journal of Pharmaceutical Sciences. 102: 2136-51
Majumdar R, Manikwar P, Hickey JM, et al. (2013) Effects of salts from the Hofmeister series on the conformational stability, aggregation propensity, and local flexibility of an IgG1 monoclonal antibody. Biochemistry. 52: 3376-89
Büyüktimkin B, Manikwar P, Kiptoo PK, et al. (2013) Vaccinelike and prophylactic treatments of EAE with novel I-domain antigen conjugates (IDAC): targeting multiple antigenic peptides to APC. Molecular Pharmaceutics. 10: 297-306
Majumdar R, Manikwar P, Hickey JM, et al. (2012) Minimizing carry-over in an online pepsin digestion system used for the H/D exchange mass spectrometric analysis of an IgG1 monoclonal antibody. Journal of the American Society For Mass Spectrometry. 23: 2140-8
Manikwar P, Büyüktimkin B, Kiptoo P, et al. (2012) I-domain-antigen conjugate (IDAC) for delivering antigenic peptides to APC: synthesis, characterization, and in vivo EAE suppression. Bioconjugate Chemistry. 23: 509-17
Manikwar P, Kiptoo P, Badawi AH, et al. (2012) Antigen-specific blocking of CD4-specific immunological synapse formation using BPI and current therapies for autoimmune diseases. Medicinal Research Reviews. 32: 727-64
Manikwar P, Zimmerman T, Blanco FJ, et al. (2011) Rapid identification of fluorochrome modification sites in proteins by LC ESI-Q-TOF mass spectrometry. Bioconjugate Chemistry. 22: 1330-6
Manikwar P, Tejo BA, Shinogle H, et al. (2011) Utilization of I-domain of LFA-1 to Target Drug and Marker Molecules to Leukocytes. Theranostics. 1: 277-89
Chittasupho C, Manikwar P, Krise JP, et al. (2010) cIBR effectively targets nanoparticles to LFA-1 on acute lymphoblastic T cells. Molecular Pharmaceutics. 7: 146-55
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