Jeffery L. Brodsky
Affiliations: | University of Pittsburgh, Pittsburgh, PA, United States |
Area:
Virology Biology, Molecular Biology, BiochemistryGoogle:
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Publications
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| Chung WJ, Goeckeler-Fried JL, Havasi V, et al. (2016) Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics. Plos One. 11: e0163615 |
| Manos-Turvey A, Al-Ashtal HA, Needham PG, et al. (2016) Dihydropyrimidinones and -thiones with improved activity against human polyomavirus family members. Bioorganic & Medicinal Chemistry Letters |
| Manos-Turvey A, Brodsky JL, Wipf P. (2016) The effect of structure and mechanism of the Hsp70 chaperone on the ability to identify chemical modulators and therapeutics Topics in Medicinal Chemistry. 19: 81-129 |
| An P, Brodsky JL, Pipas JM. (2015) The conserved core enzymatic activities and the distinct dynamics of polyomavirus large T antigens. Archives of Biochemistry and Biophysics. 573: 23-31 |
| Sabnis AJ, Guerriero CJ, Brodsky JL, et al. (2015) Abstract 481: Rationale for targeting the protein chaperone network in rhabdomyosarcoma Cancer Research. 75: 481-481 |
| Howe MK, Bodoor K, Carlson DA, et al. (2014) Identification of an allosteric small-molecule inhibitor selective for the inducible form of heat shock protein 70. Chemistry & Biology. 21: 1648-59 |
| Ireland AW, Gobillot TA, Gupta T, et al. (2014) Synthesis and structure–activity relationships of small molecule inhibitors of the simian virus 40 T antigen oncoprotein, an anti-polyomaviral target. Bioorganic & Medicinal Chemistry. 22: 6490-502 |
| Adam C, Baeurle A, Brodsky JL, et al. (2014) The HSP70 modulator MAL3-101 inhibits Merkel cell carcinoma. Plos One. 9: e92041 |
| Kang Y, Taldone T, Patel HJ, et al. (2014) Heat shock protein 70 inhibitors. 1. 2,5'-thiodipyrimidine and 5-(phenylthio)pyrimidine acrylamides as irreversible binders to an allosteric site on heat shock protein 70. Journal of Medicinal Chemistry. 57: 1188-207 |
| Simon N, Bochman ML, Seguin S, et al. (2013) Ciprofloxacin is an inhibitor of the Mcm2-7 replicative helicase. Bioscience Reports. 33 |