William A. Pastor, Ph.D.

Affiliations: 
2011 Harvard University, Cambridge, MA, United States 
Area:
Molecular Biology, Biochemistry
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Anjana Rao grad student 2011 Harvard
 (Studies of 5.8S ribosomal RNA biogenesis and 5-hydroxymethylcytosine mapping.)
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Publications

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Graham-Paquin AL, Saini D, Sirois J, et al. (2023) ZMYM2 is essential for methylation of germline genes and active transposons in embryonic development. Nucleic Acids Research. 51: 7314-7329
Pastor WA, Kwon SY. (2022) Distinctive aspects of the placental epigenome and theories as to how they arise. Cellular and Molecular Life Sciences : Cmls. 79: 569
Chen H, Hu B, Horth C, et al. (2022) H3K36 dimethylation shapes the epigenetic interaction landscape by directing repressive chromatin modifications in embryonic stem cells. Genome Research
Azevedo Portilho N, Saini D, Hossain I, et al. (2021) The DNMT1 inhibitor GSK-3484862 mediates global demethylation in murine embryonic stem cells. Epigenetics & Chromatin. 14: 56
Liu X, Ouyang JF, Rossello FJ, et al. (2020) Reprogramming roadmap reveals route to human induced trophoblast stem cells. Nature
Chen D, Liu W, Zimmerman J, et al. (2018) The TFAP2C-Regulated OCT4 Naive Enhancer Is Involved in Human Germline Formation. Cell Reports. 25: 3591-3602.e5
Pastor WA, Liu W, Chen D, et al. (2018) TFAP2C regulates transcription in human naive pluripotency by opening enhancers. Nature Cell Biology. 20: 553-564
Morselli M, Pastor WA, Montanini B, et al. (2017) Correction: In vivo targeting of de novo DNA methylation by histone modifications in yeast and mouse. Elife. 6
Tsagaratou A, González-Avalos E, Rautio S, et al. (2017) TET proteins regulate the lineage specification and TCR-mediated expansion of iNKT cells. Nature Immunology. 18: 45-53
Li X, Yue X, Pastor WA, et al. (2016) Tet proteins influence the balance between neuroectodermal and mesodermal fate choice by inhibiting Wnt signaling. Proceedings of the National Academy of Sciences of the United States of America
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