Vikas K. Sharma, Ph.D.
Affiliations: | 2003 | University of Connecticut, Storrs, CT, United States |
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Parents
Sign in to add mentor| Devendra S. Kalonia | grad student | 2003 | University of Connecticut | |
| (Formulation of proteins as dry powders by vacuum drying following precipitation by polyethylene glycols.) | ||||
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Publications
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| Sharma VK, Patapoff TW, Kabakoff B, et al. (2014) In silico selection of therapeutic antibodies for development: viscosity, clearance, and chemical stability. Proceedings of the National Academy of Sciences of the United States of America. 111: 18601-6 |
| Connolly BD, Tran B, Moore JM, et al. (2014) Specific catalysis of asparaginyl deamidation by carboxylic acids: kinetic, thermodynamic, and quantitative structure-property relationship analyses. Molecular Pharmaceutics. 11: 1345-58 |
| Abbas SA, Sharma VK, Patapoff TW, et al. (2013) Characterization of antibody-polyol interactions by static light scattering: implications for physical stability of protein formulations. International Journal of Pharmaceutics. 448: 382-9 |
| Abbas SA, Gaspar G, Sharma VK, et al. (2013) Application of second-derivative fluorescence spectroscopy to monitor subtle changes in a monoclonal antibody structure. Journal of Pharmaceutical Sciences. 102: 52-61 |
| Gomez N, Subramanian J, Ouyang J, et al. (2012) Culture temperature modulates aggregation of recombinant antibody in cho cells. Biotechnology and Bioengineering. 109: 125-36 |
| Abbas SA, Sharma VK, Patapoff TW, et al. (2012) Opposite effects of polyols on antibody aggregation: thermal versus mechanical stresses. Pharmaceutical Research. 29: 683-94 |
| Abbas SA, Sharma VK, Patapoff TW, et al. (2011) Solubilities and transfer free energies of hydrophobic amino acids in polyol solutions: importance of the hydrophobicity of polyols. Journal of Pharmaceutical Sciences. 100: 3096-104 |
| Kumar V, Chari R, Sharma VK, et al. (2011) Modulation of the thermodynamic stability of proteins by polyols: significance of polyol hydrophobicity and impact on the chemical potential of water. International Journal of Pharmaceutics. 413: 19-28 |
| Lazar KL, Patapoff TW, Sharma VK. (2010) Cold denaturation of monoclonal antibodies. Mabs. 2: 42-52 |
| Sharma VK, Kalonia DS. (2010) Experimental Detection and Characterization of Protein Aggregates Aggregation of Therapeutic Proteins. 205-256 |