Shihao Chen, Ph.D.

Affiliations: 
2002 University of Toronto, Toronto, ON, Canada 
Area:
Biochemistry
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"Shihao Chen"
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Harry Schachter grad student 2002 University of Toronto
 (Caenorhabditis elegans beta1,2 N-acetylglucosaminyltransferase I (GnT I) genes and functions.)
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Publications

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Chen S, Spence AM, Schachter H. (2003) Isolation of null alleles of the Caenorhabditis elegans gly-12, gly-13 and gly-14 genes, all of which encode UDP-GlcNAc: alpha-3-D-mannoside beta1,2-N-acetylglucosaminyltransferase I activity. Biochimie. 85: 391-401
Zhang W, Cao P, Chen S, et al. (2003) Synthesis of paucimannose N-glycans by Caenorhabditis elegans requires prior actions of UDP-N-acetyl-D-glucosamine:alpha-3-D-mannoside beta1,2-N-acetylglucosaminyltransferase I, alpha3,6-mannosidase II and a specific membrane-bound beta-N-acetylglucosaminidase. The Biochemical Journal. 372: 53-64
Schachter H, Chen S, Zhang W, et al. (2002) Functional post-translational proteomics approach to study the role of N-glycans in the development of Caenorhabditis elegans. Biochemical Society Symposium. 1-21
Chen S, Tan J, Reinhold VN, et al. (2002) UDP-N-acetylglucosamine:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I and UDP-N-acetylglucosamine:alpha-6-D-mannoside beta-1,2-N-acetylglucosaminyltransferase II in Caenorhabditis elegans. Biochimica Et Biophysica Acta. 1573: 271-9
Chen S, Spence AM, Schachter H. (2001) Complex NGlycans - When, Why? Trends in Glycoscience and Glycotechnology. 13: 447-462
Chen S, Zhou S, Sarkar M, et al. (1999) Expression of three Caenorhabditis elegans N-acetylglucosaminyltransferase I genes during development. The Journal of Biological Chemistry. 274: 288-97
Chen SH, Zhou S, Tan J, et al. (1998) Transcriptional regulation of the human UDP-GlcNAc:alpha-6-D-mannoside beta-1-2-N-acetylglucosaminyltransferase II gene (MGAT2) which controls complex N-glycan synthesis. Glycoconjugate Journal. 15: 301-8
Schachter H, Tan J, Sarkar M, et al. (1998) Defective glycosyltransferases are not good for your health. Advances in Experimental Medicine and Biology. 435: 9-27
Yip B, Chen SH, Mulder H, et al. (1997) Organization of the human beta-1,2-N-acetylglucosaminyltransferase I gene (MGAT1), which controls complex and hybrid N-glycan synthesis. The Biochemical Journal. 321: 465-74
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