George H. Silva, Ph.D.

Affiliations: 
2004 State University of New York, Albany, Albany, NY, United States 
Area:
Molecular Biology, General Biophysics, Genetics
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"George Silva"
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Parents

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Marlene Belfort grad student 2004 SUNY Albany
 (Structural and biochemical analysis of the thermostable archaeal intron -encoded endonuclease I -DmoI.)
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Publications

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Stella S, Molina R, Yefimenko I, et al. (2013) Structure of the AvrBs3-DNA complex provides new insights into the initial thymine-recognition mechanism. Acta Crystallographica. Section D, Biological Crystallography. 69: 1707-16
Singh P, Tripathi P, Silva GH, et al. (2009) Characterization of Mycobacterium leprae RecA intein, a LAGLIDADG homing endonuclease, reveals a unique mode of DNA binding, helical distortion, and cleavage compared with a canonical LAGLIDADG homing endonuclease. The Journal of Biological Chemistry. 284: 25912-28
Silva GH, Belfort M, Wende W, et al. (2006) From monomeric to homodimeric endonucleases and back: engineering novel specificity of LAGLIDADG enzymes. Journal of Molecular Biology. 361: 744-54
Silva GH, Belfort M. (2004) Analysis of the LAGLIDADG interface of the monomeric homing endonuclease I-DmoI. Nucleic Acids Research. 32: 3156-68
Silva GH, Dalgaard JZ, Belfort M, et al. (1999) Crystal structure of the thermostable archaeal intron-encoded endonuclease I-DmoI. Journal of Molecular Biology. 286: 1123-36
Dalgaard JZ, Silva GH, Belfort M, et al. (1998) Crystallization and preliminary crystallographic analysis of the archaeal intron-encoded endonuclease I-DmoI. Acta Crystallographica. Section D, Biological Crystallography. 54: 1435-6
Loizos N, Silva GH, Belfort M. (1996) Intron-encoded endonuclease I-TevII binds across the minor groove and induces two distinct conformational changes in its DNA substrate. Journal of Molecular Biology. 255: 412-24
Silva GH, Dalgaard JZ, Belfort M, et al. (1996) Crystallographic studies of the archaeal intron encoded endonuclease I-DmoIl Acta Crystallographica Section a Foundations of Crystallography. 52: C159-C159
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