Keriann M. Oertell, Ph.D.

Affiliations: 
2013 Chemistry University of Southern California, Los Angeles, CA, United States 
Area:
Biochemistry
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"Keriann Oertell"
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Parents

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Myron Goodman grad student 2013 USC
 (DNA polymerase mechanism and fidelity: Using beta,gamma-bridging oxygen substituted dNTPs to study the mechanism of DNA polymerase beta.)
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Publications

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Oertell K, Florian J, Haratipour P, et al. (2019) A Transition-State Perspective on Y-Family DNA Polymerase η Fidelity in Comparison with X-Family DNA Polymerases λ and β. Biochemistry
Oertell K, Kashemirov BA, Negahbani A, et al. (2018) Probing DNA base-dependent leaving group kinetic effects on the DNA polymerase transition state. Biochemistry
Batra VK, Oertell K, Beard WA, et al. (2018) Mapping functional substrate-enzyme interactions in the pol β active site through chemical biology: Structural responses to acidity modification of incoming dNTPs. Biochemistry
Oertell K, Harcourt EM, Mohsen MG, et al. (2016) Kinetic selection vs. free energy of DNA base pairing in control of polymerase fidelity. Proceedings of the National Academy of Sciences of the United States of America
Kadina AP, Kashemirov BA, Oertell K, et al. (2015) Two Scaffolds from Two Flips: (α,β)/(β,γ) CH2/NH "Met-Im" Analogues of dTTP. Organic Letters. 17: 2586-9
Shakhmin A, Jones JP, Bychinskaya I, et al. (2014) Preparation of fluorinated RNA nucleotide analogs potentially stable to enzymatic hydrolysis in RNA and DNA polymerase assays. Journal of Fluorine Chemistry. 167: 226-230
Oertell K, Chamberlain BT, Wu Y, et al. (2014) Transition state in DNA polymerase β catalysis: rate-limiting chemistry altered by base-pair configuration. Biochemistry. 53: 1842-8
Shakhmin A, Jones JP, Bychinskaya I, et al. (2014) Preparation of fluorinated RNA nucleotide analogs potentially stable to enzymatic hydrolysis in RNA and DNA polymerase assays Journal of Fluorine Chemistry
Oertell K, Wu Y, Zakharova VM, et al. (2012) Effect of β,γ-CHF- and β,γ-CHCl-dGTP halogen atom stereochemistry on the transition state of DNA polymerase β. Biochemistry. 51: 8491-501
Surya Prakash GK, Zibinsky M, Upton TG, et al. (2010) Synthesis and biological evaluation of fluorinated deoxynucleotide analogs based on bis-(difluoromethylene)triphosphoric acid. Proceedings of the National Academy of Sciences of the United States of America. 107: 15693-8
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