Robert C. van Waardenburg
Affiliations: | Pharmacology and Toxicology | University of Alabama, Birmingham, Birmingham, AL, United States |
Area:
Molecular Biology, BiochemistryGoogle:
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Publications
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| Cuya SM, Comeaux EQ, Wanzeck K, et al. (2016) Dysregulated human Tyrosyl-DNA phosphodiesterase I acts as cellular toxin. Oncotarget |
| van Waardenburg RC. (2016) Tyrosyl-DNA Phosphodiesterase I a critical survival factor for neuronal development and homeostasis. Journal of Neurology & Neuromedicine. 1: 25-29 |
| Comeaux EQ, Cuya SM, Kojima K, et al. (2015) Tyrosyl-DNA phosphodiesterase I catalytic mutants reveal an alternative nucleophile that can catalyze substrate cleavage. The Journal of Biological Chemistry. 290: 6203-14 |
| Comeaux EQ, van Waardenburg RC. (2014) Tyrosyl-DNA phosphodiesterase I resolves both naturally and chemically induced DNA adducts and its potential as a therapeutic target. Drug Metabolism Reviews. 46: 494-507 |
| Gajewski S, Comeaux EQ, Jafari N, et al. (2012) Analysis of the active-site mechanism of tyrosyl-DNA phosphodiesterase I: a member of the phospholipase D superfamily. Journal of Molecular Biology. 415: 741-58 |
| He X, van Waardenburg RC, Babaoglu K, et al. (2007) Mutation of a conserved active site residue converts tyrosyl-DNA phosphodiesterase I into a DNA topoisomerase I-dependent poison. Journal of Molecular Biology. 372: 1070-81 |
| van Waardenburg RC, Duda DM, Lancaster CS, et al. (2006) Distinct functional domains of Ubc9 dictate cell survival and resistance to genotoxic stress. Molecular and Cellular Biology. 26: 4958-69 |
| Jacquiau HR, van Waardenburg RC, Reid RJ, et al. (2005) Defects in SUMO (small ubiquitin-related modifier) conjugation and deconjugation alter cell sensitivity to DNA topoisomerase I-induced DNA damage. The Journal of Biological Chemistry. 280: 23566-75 |
| van Waardenburg RC, de Jong LA, van Eijndhoven MA, et al. (2004) Platinated DNA adducts enhance poisoning of DNA topoisomerase I by camptothecin. The Journal of Biological Chemistry. 279: 54502-9 |
| van Waardenburg RC, de Jong LA, van Delft F, et al. (2004) Homologous recombination is a highly conserved determinant of the synergistic cytotoxicity between cisplatin and DNA topoisomerase I poisons. Molecular Cancer Therapeutics. 3: 393-402 |