Ali Ozuer, Ph.D.

Affiliations: 
2002 University of Pittsburgh, Pittsburgh, PA, United States 
Area:
Chemical Engineering, Biomedical Engineering, Cell Biology
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Mohammad M. Ataai grad student 2002 University of Pittsburgh
 (Scaling-up the production and purification of HSV-based gene therapy vectors and development of GLP assay system to analyze quantity and quality of clinical-grade HSV vector stocks.)
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Publications

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Uchida H, Shah WA, Ozuer A, et al. (2009) Generation of herpesvirus entry mediator (HVEM)-restricted herpes simplex virus type 1 mutant viruses: resistance of HVEM-expressing cells and identification of mutations that rescue nectin-1 recognition. Journal of Virology. 83: 2951-61
Tsvitov M, Frampton AR, Shah WA, et al. (2007) Characterization of soluble glycoprotein D-mediated herpes simplex virus type 1 infection. Virology. 360: 477-91
Jiang C, Ataai M, Ozuer A, et al. (2006) Inactivation of herpes simplex type 1 gene vector on immobilized metal affinity chromatography: oxidative damage by hydroxyl free radicals and its prevention. Biotechnology and Bioengineering. 95: 48-57
Krisky DM, Wechuck J, Wolfe D, et al. (2005) 757. Replication Defective HSV-1 Immediate Early (IE) Gene Mutants: A Comparison of Vector Toxicity Versus Transgene Expression Molecular Therapy. 11
Jiang C, Wechuck J, Ozuer A, et al. (2005) Reducing agents and imidazole protect Hsv-1 vector from inactivation during immobilized cobalt affinity chromatography Aiche Annual Meeting, Conference Proceedings. 12145
Wolfe D, Niranjan A, Trichel A, et al. (2004) Safety and biodistribution studies of an HSV multigene vector following intracranial delivery to non-human primates. Gene Therapy. 11: 1675-84
Wolfe D, Wechuck JB, Krisky DM, et al. (2004) Delivery of herpes simplex virus-based vectors to stem cells. Methods in Molecular Biology (Clifton, N.J.). 246: 339-52
Wechuck JB, Ozuer A, Goins WF, et al. (2002) Effect of temperature, medium composition, and cell passage on production of herpes-based viral vectors. Biotechnology and Bioengineering. 79: 112-9
Ozuer A, Wechuck JB, Russell B, et al. (2002) Evaluation of infection parameters in the production of replication-defective HSV-1 viral vectors. Biotechnology Progress. 18: 476-82
Ozuer A, Wechuck JB, Goins WF, et al. (2002) Effect of genetic background and culture conditions on the production of herpesvirus-based gene therapy vectors. Biotechnology and Bioengineering. 77: 685-92
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