Tyson R. Shepherd, Ph.D.
Affiliations: | 2011 | Biochemistry | University of Iowa, Iowa City, IA |
Area:
Biochemistry, General BiophysicsGoogle:
"Tyson Shepherd"Mean distance: (not calculated yet)
Parents
Sign in to add mentor| Ernesto J. Fuentes | grad student | 2011 | University of Iowa | |
| (Structural and thermodynamic origins of distinct ligand specificity of two homologous PDZ domains.) | ||||
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Publications
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| Liu X, Golden LC, Lopez JA, et al. (2019) Conformational Dynamics and Cooperativity Drive the Specificity of a Protein-Ligand Interaction. Biophysical Journal |
| Liu X, Speckhard DC, Shepherd TR, et al. (2016) Distinct Roles for Conformational Dynamics in Protein-Ligand Interactions. Structure (London, England : 1993). 24: 2053-2066 |
| Fuentes EJ, Liu X, Speckhard DC, et al. (2016) Conformational Dynamics and Structure Underlie the Novel Ligand Binding Specificity of a Tiam1 PDZ Domain Mutant Biophysical Journal. 110: 514a |
| Fuentes EJ, Liu X, Speckhard DC, et al. (2014) Structural and Dynamic Features Underlie the Switch of Ligand Binding Specificity in a Tiam1 PDZ Domain Mutant Biophysical Journal. 106: 661a |
| Punekar AS, Liljeruhm J, Shepherd TR, et al. (2013) Structural and functional insights into the molecular mechanism of rRNA m6A methyltransferase RlmJ. Nucleic Acids Research. 41: 9537-48 |
| Liu Y, Collins C, Kiosses WB, et al. (2013) A novel pathway spatiotemporally activates Rac1 and redox signaling in response to fluid shear stress. The Journal of Cell Biology. 201: 863-73 |
| Liu X, Shepherd TR, Murray AM, et al. (2013) The structure of the Tiam1 PDZ domain/ phospho-syndecan1 complex reveals a ligand conformation that modulates protein dynamics. Structure (London, England : 1993). 21: 342-54 |
| Punekar AS, Shepherd TR, Liljeruhm J, et al. (2012) Crystal structure of RlmM, the 2'O-ribose methyltransferase for C2498 of Escherichia coli 23S rRNA. Nucleic Acids Research. 40: 10507-20 |
| Fuentes EJ, Liu X, Shepherd TR, et al. (2012) Specificity, Structure and Dynamics of Tiam1 PDZ Domain Ligand-Bound Complexes Biophysical Journal. 102: 411a |
| Shepherd TR, Fuentes EJ. (2011) Structural and thermodynamic analysis of PDZ-ligand interactions. Methods in Enzymology. 488: 81-100 |