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David Svilar, Ph.D.

Affiliations: 
2012 Molecular Pharmacology University of Pittsburgh, Pittsburgh, PA, United States 
Area:
Pharmacology, Oncology, Biochemistry
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Robert W. Sobol grad student 2012 University of Pittsburgh
 (DNA glycosylases as modulators of chemotherapeutic response.)

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Li J, Svilar D, McClellan S, et al. (2018) DNA Repair Molecular Beacon assay: a platform for real-time functional analysis of cellular DNA repair capacity. Oncotarget. 9: 31719-31743
Fang Q, Inanc B, Schamus S, et al. (2014) HSP90 regulates DNA repair via the interaction between XRCC1 and DNA polymerase β. Nature Communications. 5: 5513
Nagaria P, Svilar D, Brown AR, et al. (2013) SMUG1 but not UNG DNA glycosylase contributes to the cellular response to recovery from 5-fluorouracil induced replication stress. Mutation Research. 743: 26-32
Iyer P, Srinivasan A, Singh SK, et al. (2013) Synthesis and characterization of DNA minor groove binding alkylating agents. Chemical Research in Toxicology. 26: 156-68
Svilar D, Dyavaiah M, Brown AR, et al. (2012) Alkylation sensitivity screens reveal a conserved cross-species functionome. Molecular Cancer Research : McR. 10: 1580-96
Svilar D, Vens C, Sobol RW. (2012) Quantitative, real-time analysis of base excision repair activity in cell lysates utilizing lesion-specific molecular beacons. Journal of Visualized Experiments : Jove. e4168
Goellner EM, Svilar D, Almeida KH, et al. (2012) Targeting DNA polymerase ß for therapeutic intervention. Current Molecular Pharmacology. 5: 68-87
Mutamba JT, Svilar D, Prasongtanakij S, et al. (2011) XRCC1 and base excision repair balance in response to nitric oxide. Dna Repair. 10: 1282-93
Tang JB, Svilar D, Trivedi RN, et al. (2011) N-methylpurine DNA glycosylase and DNA polymerase beta modulate BER inhibitor potentiation of glioma cells to temozolomide. Neuro-Oncology. 13: 471-86
Svilar D, Goellner EM, Almeida KH, et al. (2011) Base excision repair and lesion-dependent subpathways for repair of oxidative DNA damage. Antioxidants & Redox Signaling. 14: 2491-507
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