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Chad N. Brocker, Ph.D.

Affiliations: 
2012 University of Colorado Anschutz Medical Campus, Denver, Aurora, CO 
Area:
Toxicology, Biochemistry
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Vasilis Vasiliou grad student 2012 University of Colorado, Denver
 (Characterization of aldehyde dehydrogenase 7A1 (ALDH7A1) and the potential mechanisms underlying pyridoxine-dependent epilepsy.)

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Xie C, Takahashi S, Brocker CN, et al. (2019) Hepatocyte peroxisome proliferator-activated receptor alpha regulates bile acid synthesis and transport. Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids
Kim D, Brocker CN, Takahashi S, et al. (2019) Keratin 23 is a PPARA-dependent, MYC-amplified oncogene that promotes hepatocyte proliferation. Hepatology (Baltimore, Md.)
Xie G, Yin S, Zhang ZZ, et al. (2018) Hepatocyte PPARα enhances liver regeneration after partial hepatectomy in mice. The American Journal of Pathology
Brocker CN, Patel DP, Velenosi TJ, et al. (2018) Extrahepatic PPARα modulates fatty acid oxidation and attenuates fasting-induced hepatosteatosis in mice. Journal of Lipid Research
Li G, Brocker CN, Yan T, et al. (2017) Metabolic adaptation to intermittent fasting is independent of peroxisome proliferator-activated receptor alpha. Molecular Metabolism
Li G, Brocker CN, Xie C, et al. (2017) Hepatic PPARα mediates the major metabolic effects of Wy-14643. Journal of Gastroenterology and Hepatology
Brocker CN, Yue J, Kim D, et al. (2017) Hepatocyte-specific PPARA expression exclusively promotes agonist-induced cell proliferation without influence from non-parenchymal cells. American Journal of Physiology. Gastrointestinal and Liver Physiology. ajpgi.00205.2016
Gonzalez FJ, Xie C, Jiang C, et al. (2017) The role of toxic lipids metabolic disease Drug Metabolism and Pharmacokinetics. 32
Burdin DV, Kolobov AA, Brocker C, et al. (2016) Diabetes-linked transcription factor HNF4α regulates metabolism of endogenous methylarginines and β-aminoisobutyric acid by controlling expression of alanine-glyoxylate aminotransferase 2. Scientific Reports. 6: 35503
Takahashi S, Fukami T, Masuo Y, et al. (2016) Cyp2c70 is responsible for the species difference in bile acid metabolism between mice and humans. Journal of Lipid Research
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