Florence F. Wagner, Ph.D.

Affiliations: 
2006 North Carolina State University, Raleigh, NC 
Area:
Organic Chemistry
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"Florence Wagner"
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Daniel L. Comins grad student 2006 NCSU
 (Synthesis of nicotine derivatives from natural nicotine, total synthesis of (S)-Brevicolline and advances towards the synthesis of dihydrolycolucine.)
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Publications

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McCamphill PK, Stoppel LJ, Senter RK, et al. (2020) Selective inhibition of glycogen synthase kinase 3α corrects pathophysiology in a mouse model of fragile X syndrome. Science Translational Medicine. 12
Strebl MG, Campbell AJ, Zhao WN, et al. (2017) HDAC6 Brain Mapping with [(18)F]Bavarostat Enabled by a Ru-Mediated Deoxyfluorination. Acs Central Science. 3: 1006-1014
Schuetze KB, Stratton MS, Blakeslee WW, et al. (2017) Overlapping and Divergent Actions of Structurally Distinct HDAC Inhibitors in Cardiac Fibroblasts. The Journal of Pharmacology and Experimental Therapeutics
Wagner FF, Weïwer M, Steinbacher S, et al. (2016) Kinetic and structural insights into the binding of histone deacetylase 1 and 2 (HDAC1, 2) inhibitors. Bioorganic & Medicinal Chemistry
Wagner FF, Bishop JA, Gale JP, et al. (2016) Inhibitors of Glycogen Synthase Kinase 3 with Exquisite Kinome-wide Selectivity and their Functional Effects. Acs Chemical Biology
Wagner FF, Lundh M, Kaya T, et al. (2015) An Isochemogenic Set of Inhibitors To Define the Therapeutic Potential of Histone Deacetylases in β-Cell Protection. Acs Chemical Biology
Olson DE, Sleiman SF, Bourassa MW, et al. (2015) Hydroxamate-based histone deacetylase inhibitors can protect neurons from oxidative stress via a histone deacetylase-independent catalase-like mechanism. Chemistry & Biology. 22: 439-45
Wagner FF, Zhang YL, Fass DM, et al. (2015) Kinetically Selective Inhibitors of Histone Deacetylase 2 (HDAC2) as Cognition Enhancers. Chemical Science (Royal Society of Chemistry : 2010). 6: 804-815
Benajiba L, Wagner F, Ross L, et al. (2015) Identification of a First in Class GSK3-Alpha Selective Inhibitor As a New Differentiation Therapy for AML Blood. 126: 870-870
Sleiman SF, Olson DE, Bourassa MW, et al. (2014) Hydroxamic acid-based histone deacetylase (HDAC) inhibitors can mediate neuroprotection independent of HDAC inhibition. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 14328-37
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